Venous thromboembolism (VTE) is a major national health problem and the recent Surgeon General's Call to Action identified key gaps in knowledge which we will specifically address.
Our specific aims are in Aim 1 determine "why VTE remains such a persistent problem" by updating the Olmsted County, MN VTE inception cohort to include the 45-year period, 1966-2010, and 1a) test whether recently implemented CMS performance measures have affected secular trends in VTE incidence and prophylaxis- related complications, 1b) quantify changes over time in the population-attributable risk of major VTE risk factors, and 1c) determine whether changes in the prevalence of major VTE risk factors can account for trends in the observed incidence of VTE;
in Aim 2 to determine "when genetic testing is appropriate" by 2a) testing Factor V Leiden, Prothrombin G20210A, and novel ABO SNPs as risk factors for VTE after hospitalization for major surgery and acute medical illness, and 2b) developing and 2c) validating VTE risk assessment tools for these two high-risk populations;
in Aim 3 to "conduct research into how [arm] DVT should best be managed" by identifying all Olmsted County residents with incident arm cerebral, hepatic, portal, splenic, mesenteric and renal vein thrombosis and 3a) estimate the incidence of thrombosis in these "other" venous circulations, 3b) quantify outcomes (survival and VTE recurrence), and 3c) test other venous circulation thrombosis as potential predictors of survival and VTE recurrence;and in Aim 4 to "investigate the roles of IVC filters" by identifying all Olmsted Count residents with IVC filter placement over the 45-year period, 1966-2010, and 4a) estimate the incidence of IVC interruption or filter placement, 4b) determine outcomes (survival, complications and VTE incidence and recurrence), and 4c) test IVC filter placement as a risk factor for incident VTE, or as predictors of survival and recurrent VTE.
Almost one million people suffer venous thromboembolism annually in the United States, and one-third die from this disease. This study aims to prevent these deaths by identifying the individual person at high risk and preventing venous thromboembolism.
|Chee, Cheng E; Ashrani, Aneel A; Marks, Randolph S et al. (2014) Predictors of venous thromboembolism recurrence and bleeding among active cancer patients: a population-based cohort study. Blood 123:3972-8|
|Barsoum, Michel K; Cohoon, Kevin P; Roger, Véronique L et al. (2014) Are myocardial infarction and venous thromboembolism associated? Population-based case-control and cohort studies. Thromb Res 134:593-8|
|Cohoon, Kevin P; Heit, John A (2014) Inherited and secondary thrombophilia. Circulation 129:254-7|
|Leibson, Cynthia L; Petterson, Tanya M; Smith, Carin Y et al. (2014) Rethinking guidelines for VTE risk among nursing home residents: a population-based study merging medical record detail with standardized nursing home assessments. Chest 146:412-21|
|Froehling, David A; Daniels, Paul R; Mauck, Karen F et al. (2013) Incidence of venous thromboembolism after bariatric surgery: a population-based cohort study. Obes Surg 23:1874-9|
|Mauck, K F; Froehling, D A; Daniels, P R et al. (2013) Incidence of venous thromboembolism after elective knee arthroscopic surgery: a historical cohort study. J Thromb Haemost 11:1279-86|
|Heit, John A (2013) Cardiovascular endocrinology: Risk of venous thromboembolism with glucocorticoids. Nat Rev Endocrinol 9:387-8|
|Cohoon, Kevin P; Heit, John A (2013) Should platelet function testing guide antiplatelet therapy for patients with coronary artery stenting or acute coronary syndromes? Clin Chem 59:1299-300|
|Bacani, A Kirstin; Gabriel, Sherine E; Crowson, Cynthia S et al. (2012) Noncardiac vascular disease in rheumatoid arthritis: increase in venous thromboembolic events? Arthritis Rheum 64:53-61|
|Heit, John A (2012) Predicting the risk of venous thromboembolism recurrence. Am J Hematol 87 Suppl 1:S63-7|
Showing the most recent 10 out of 32 publications