Venous thromboembolism (VTE) is a major national health problem and the recent Surgeon General's Call to Action identified key gaps in knowledge which we will specifically address.
Our specific aims are in Aim 1 determine """"""""why VTE remains such a persistent problem"""""""" by updating the Olmsted County, MN VTE inception cohort to include the 45-year period, 1966-2010, and 1a) test whether recently implemented CMS performance measures have affected secular trends in VTE incidence and prophylaxis- related complications, 1b) quantify changes over time in the population-attributable risk of major VTE risk factors, and 1c) determine whether changes in the prevalence of major VTE risk factors can account for trends in the observed incidence of VTE;
in Aim 2 to determine """"""""when genetic testing is appropriate"""""""" by 2a) testing Factor V Leiden, Prothrombin G20210A, and novel ABO SNPs as risk factors for VTE after hospitalization for major surgery and acute medical illness, and 2b) developing and 2c) validating VTE risk assessment tools for these two high-risk populations;
in Aim 3 to """"""""conduct research into how [arm] DVT should best be managed"""""""" by identifying all Olmsted County residents with incident arm cerebral, hepatic, portal, splenic, mesenteric and renal vein thrombosis and 3a) estimate the incidence of thrombosis in these """"""""other"""""""" venous circulations, 3b) quantify outcomes (survival and VTE recurrence), and 3c) test other venous circulation thrombosis as potential predictors of survival and VTE recurrence;and in Aim 4 to """"""""investigate the roles of IVC filters"""""""" by identifying all Olmsted Count residents with IVC filter placement over the 45-year period, 1966-2010, and 4a) estimate the incidence of IVC interruption or filter placement, 4b) determine outcomes (survival, complications and VTE incidence and recurrence), and 4c) test IVC filter placement as a risk factor for incident VTE, or as predictors of survival and recurrent VTE.
Almost one million people suffer venous thromboembolism annually in the United States, and one-third die from this disease. This study aims to prevent these deaths by identifying the individual person at high risk and preventing venous thromboembolism.
|Cohoon, Kevin P; Ashrani, Aneel A; Crusan, Daniel J et al. (2018) Is Infection an Independent Risk Factor for Venous Thromboembolism? A Population-Based, Case-Control Study. Am J Med 131:307-316.e2|
|Petterson, Tanya M; Smith, Carin Y; Emerson, Jane A et al. (2018) Venous Thromboembolism (VTE) Incidence and VTE-Associated Survival among Olmsted County Residents of Local Nursing Homes. Thromb Haemost 118:1316-1328|
|Lindström, Sara; Germain, Marine; Crous-Bou, Marta et al. (2017) Assessing the causal relationship between obesity and venous thromboembolism through a Mendelian Randomization study. Hum Genet 136:897-902|
|Heit, John A; Crusan, Daniel J; Ashrani, Aneel A et al. (2017) Effect of a near-universal hospitalization-based prophylaxis regimen on annual number of venous thromboembolism events in the US. Blood 130:109-114|
|Park, Myung S; Spears, Grant M; Bailey, Kent R et al. (2017) Thrombin generation profiles as predictors of symptomatic venous thromboembolism after trauma: A prospective cohort study. J Trauma Acute Care Surg 83:381-387|
|Heit, John A; Armasu, Sebastian M; McCauley, Bryan M et al. (2017) Identification of unique venous thromboembolism-susceptibility variants in African-Americans. Thromb Haemost 117:758-768|
|de Andrade, Mariza; Armasu, Sebastian M; McCauley, Bryan M et al. (2017) Identification of Genetic Interaction with Risk Factors Using a Time-To-Event Model. Int J Environ Res Public Health 14:|
|Roetker, N S; Armasu, S M; Pankow, J S et al. (2017) Taller height as a risk factor for venous thromboembolism: a Mendelian randomization meta-analysis. J Thromb Haemost 15:1334-1343|
|Heit, John A; Ashrani, Aneel; Crusan, Daniel J et al. (2017) Reasons for the persistent incidence of venous thromboembolism. Thromb Haemost 117:390-400|
|Ashrani, Aneel A; Gullerud, Rachel E; Petterson, Tanya M et al. (2016) Risk factors for incident venous thromboembolism in active cancer patients: A population based case-control study. Thromb Res 139:29-37|
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