Venous thromboembolism (VTE) is a major national health problem and the recent Surgeon General's Call to Action identified key gaps in knowledge which we will specifically address.
Our specific aims are in Aim 1 determine """"""""why VTE remains such a persistent problem"""""""" by updating the Olmsted County, MN VTE inception cohort to include the 45-year period, 1966-2010, and 1a) test whether recently implemented CMS performance measures have affected secular trends in VTE incidence and prophylaxis- related complications, 1b) quantify changes over time in the population-attributable risk of major VTE risk factors, and 1c) determine whether changes in the prevalence of major VTE risk factors can account for trends in the observed incidence of VTE;
in Aim 2 to determine """"""""when genetic testing is appropriate"""""""" by 2a) testing Factor V Leiden, Prothrombin G20210A, and novel ABO SNPs as risk factors for VTE after hospitalization for major surgery and acute medical illness, and 2b) developing and 2c) validating VTE risk assessment tools for these two high-risk populations;
in Aim 3 to """"""""conduct research into how [arm] DVT should best be managed"""""""" by identifying all Olmsted County residents with incident arm cerebral, hepatic, portal, splenic, mesenteric and renal vein thrombosis and 3a) estimate the incidence of thrombosis in these """"""""other"""""""" venous circulations, 3b) quantify outcomes (survival and VTE recurrence), and 3c) test other venous circulation thrombosis as potential predictors of survival and VTE recurrence;and in Aim 4 to """"""""investigate the roles of IVC filters"""""""" by identifying all Olmsted Count residents with IVC filter placement over the 45-year period, 1966-2010, and 4a) estimate the incidence of IVC interruption or filter placement, 4b) determine outcomes (survival, complications and VTE incidence and recurrence), and 4c) test IVC filter placement as a risk factor for incident VTE, or as predictors of survival and recurrent VTE.

Public Health Relevance

Almost one million people suffer venous thromboembolism annually in the United States, and one-third die from this disease. This study aims to prevent these deaths by identifying the individual person at high risk and preventing venous thromboembolism.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL066216-13
Application #
8688301
Study Section
Cardiovascular and Sleep Epidemiology Study Section (CASE)
Program Officer
Fabsitz, Richard
Project Start
2001-04-01
Project End
2015-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
13
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
City
Rochester
State
MN
Country
United States
Zip Code
55905
Cohoon, Kevin P; Ransom, Jeanine E; Leibson, Cynthia L et al. (2016) Direct Medical Costs Attributable to Cancer-Associated Venous Thromboembolism: A Population-Based Longitudinal Study. Am J Med 129:1000.e15-25
Ashrani, Aneel A; Gullerud, Rachel E; Petterson, Tanya M et al. (2016) Risk factors for incident venous thromboembolism in active cancer patients: A population based case-control study. Thromb Res 139:29-37
Park, Myung S; Perkins, Sarah E; Spears, Grant M et al. (2016) Risk factors for venous thromboembolism after acute trauma: A population-based case-cohort study. Thromb Res 144:40-5
Cohoon, Kevin P; Leibson, Cynthia L; Ransom, Jeanine E et al. (2015) Costs of venous thromboembolism associated with hospitalization for medical illness. Am J Manag Care 21:e255-63
Cohoon, Kevin P; Leibson, Cynthia L; Ransom, Jeanine E et al. (2015) Direct medical costs attributable to venous thromboembolism among persons hospitalized for major operation: a population-based longitudinal study. Surgery 157:423-31
Ashrani, Aneel A; Barsoum, Michel K; Crusan, Daniel J et al. (2015) Is lipid lowering therapy an independent risk factor for venous thromboembolism? A population-based case-control study. Thromb Res 135:1110-6
Heit, John A (2015) Epidemiology of venous thromboembolism. Nat Rev Cardiol 12:464-74
Heit, John A; Lahr, Brian D; Ashrani, Aneel A et al. (2015) Predictors of venous thromboembolism recurrence, adjusted for treatments and interim exposures: a population-based case-cohort study. Thromb Res 136:298-307
Petterson, Tanya M; Marks, Randolph S; Ashrani, Aneel A et al. (2015) Risk of site-specific cancer in incident venous thromboembolism: a population-based study. Thromb Res 135:472-8
Barsoum, Michel K; Cohoon, Kevin P; Roger, Véronique L et al. (2014) Are myocardial infarction and venous thromboembolism associated? Population-based case-control and cohort studies. Thromb Res 134:593-8

Showing the most recent 10 out of 44 publications