This proposal is for continued support of our Bioengineering Research Partnership entitled Biology, Biomechanics and Atherosclerosis. Over the first 4 years of our BRP funding, our group has focused on obtaining a better understanding of the basic mechanism of atherosclerosis with a particular focus on the interrelationships between biomechanical forces and atherosclerosis. Our initial efforts have been broad in scope incorporating the expertise of engineers, biologists and clinicians from an expansive range of clinical and academic areas. In this, our request for continued support, we have elected to focus our efforts on a single atherosclerotic disease entity, abdominal aortic aneurysms (AAA). We have taken this approach based on several factors including the importance of the clinical problem, the development of extensive, relevant preliminary data by members of the BRP and the potential benefit of having a greater focus for the members of the BRP. The overall goal of this BRP is to gain a better understanding of the biology and biomechanics of AAA formation with the overall goal of gaining new insights into the underlying mechanisms of AAA development. This project is support my novel data from the members of this BRP that implicate additional protein families in the maladaptive remodeling of the aortic wall that occurs during AAA formation. This proposal will focus on developing aneurysms at the earliest stages of remodeling so as to study the most biologically relevant aspects of AAA formation.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Project (R01)
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Study Section
Atherosclerosis and Inflammation of the Cardiovascular System Study Section (AICS)
Program Officer
Tolunay, Eser
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Emory University
Internal Medicine/Medicine
Schools of Medicine
United States
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Campbell, Ian C; Suever, Jonathan D; Timmins, Lucas H et al. (2014) Biomechanics and inflammation in atherosclerotic plaque erosion and plaque rupture: implications for cardiovascular events in women. PLoS One 9:e111785
Wang, Ruoya; Gleason Jr, Rudolph L (2014) Residual shear deformations in the coronary artery. J Biomech Eng 136:061004
Wang, Ruoya; Raykin, Julia; Li, Haiyan et al. (2014) Differential mechanical response and microstructural organization between non-human primate femoral and carotid arteries. Biomech Model Mechanobiol 13:1041-51
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Parastatidis, Ioannis; Weiss, Daiana; Joseph, Giji et al. (2013) Overexpression of catalase in vascular smooth muscle cells prevents the formation of abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol 33:2389-96

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