This proposal is for continued support of our Bioengineering Research Partnership entitled Biology, Biomechanics and Atherosclerosis. Over the first 4 years of our BRP funding, our group has focused on obtaining a better understanding of the basic mechanism of atherosclerosis with a particular focus on the interrelationships between biomechanical forces and atherosclerosis. Our initial efforts have been broad in scope incorporating the expertise of engineers, biologists and clinicians from an expansive range of clinical and academic areas. In this, our request for continued support, we have elected to focus our efforts on a single atherosclerotic disease entity, abdominal aortic aneurysms (AAA). We have taken this approach based on several factors including the importance of the clinical problem, the development of extensive, relevant preliminary data by members of the BRP and the potential benefit of having a greater focus for the members of the BRP. The overall goal of this BRP is to gain a better understanding of the biology and biomechanics of AAA formation with the overall goal of gaining new insights into the underlying mechanisms of AAA development. This project is support my novel data from the members of this BRP that implicate additional protein families in the maladaptive remodeling of the aortic wall that occurs during AAA formation. This proposal will focus on developing aneurysms at the earliest stages of remodeling so as to study the most biologically relevant aspects of AAA formation.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL070531-10
Application #
8300927
Study Section
Atherosclerosis and Inflammation of the Cardiovascular System Study Section (AICS)
Program Officer
Tolunay, Eser
Project Start
2002-06-01
Project End
2013-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
10
Fiscal Year
2012
Total Cost
$1,181,207
Indirect Cost
$273,911
Name
Emory University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Campbell, Ian C; Suever, Jonathan D; Timmins, Lucas H et al. (2014) Biomechanics and inflammation in atherosclerotic plaque erosion and plaque rupture: implications for cardiovascular events in women. PLoS One 9:e111785
Wang, Ruoya; Gleason Jr, Rudolph L (2014) Residual shear deformations in the coronary artery. J Biomech Eng 136:061004
Wang, Ruoya; Raykin, Julia; Li, Haiyan et al. (2014) Differential mechanical response and microstructural organization between non-human primate femoral and carotid arteries. Biomech Model Mechanobiol 13:1041-51
Rachev, Alexander; Taylor, W Robert; Vito, Raymond P (2013) Calculation of the outcomes of remodeling of arteries subjected to sustained hypertension using a 3D two-layered model. Ann Biomed Eng 41:1539-53
Passerini, T; Quaini, A; Villa, U et al. (2013) Validation of an open source framework for the simulation of blood flow in rigid and deformable vessels. Int J Numer Method Biomed Eng 29:1192-213
Campbell, Ian C; Timmins, Lucas H; Giddens, Don P et al. (2013) Computational Fluid Dynamics Simulations of Hemodynamics in Plaque Erosion. Cardiovasc Eng Technol 4:
Campbell, Ian C; Weiss, Daiana; Suever, Jonathan D et al. (2013) Biomechanical modeling and morphology analysis indicates plaque rupture due to mechanical failure unlikely in atherosclerosis-prone mice. Am J Physiol Heart Circ Physiol 304:H473-86
Zhang, Huanchun; Taylor, W Robert; Joseph, Giji et al. (2013) mRNA-binding protein ZFP36 is expressed in atherosclerotic lesions and reduces inflammation in aortic endothelial cells. Arterioscler Thromb Vasc Biol 33:1212-20
Sutliff, Roy L; Hilenski, Lula L; Amanso, Angelica M et al. (2013) Polymerase delta interacting protein 2 sustains vascular structure and function. Arterioscler Thromb Vasc Biol 33:2154-61
Parastatidis, Ioannis; Weiss, Daiana; Joseph, Giji et al. (2013) Overexpression of catalase in vascular smooth muscle cells prevents the formation of abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol 33:2389-96

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