The proposed study, Outcomes of Sleep Disorders in Older Men, will take advantage of the established cohort that has been recruited for the Osteoporotic Fractures in Men (MrOS) study (5U01AR045647 - Dr. Eric Orwoll, PI) to address a number of questions regarding the role of sleep disorders in the pathogenesis of chronic illnesses and functional disability. MrOS, a 7-year study that began in July 1999, is a multi-center prospective study of approximately 6000 men aged 65 and older. During the MrOS baseline visit, a broad variety of measurements were collected, including body composition and body fat distribution (by DEXA and quantitative computed tomography), bone density, anthropometry, performance-based tests of strength and balance, medical history, medication use, smoking and alcohol use, and other parameters. Blood, urine, and DNA specimens have been archived for use in future studies of importance to the health of older men. In a subcohort of 3000 MrOS participants, we propose to add comprehensive and accurate assessments of sleep using in-home polysomnography, wrist actigraphy, questionnaires and other measures; and prospective adjudication of CVD events, to the extensive measures that have already been performed or planned in the MrOS cohort study. These new measures will enable us to test several important hypotheses: 1) To characterize the associations between sleep disruption and subsequent CVD events during 3.5 years of follow-up; 2) To determine if sleep disturbances are associated with an increased risk of total and cause-specific mortality in older men; 3) To test whether sleep disturbances are associated with increased risk of falls and decreased physical function; 4) To test whether sleep disturbances are associated with impaired cognitive function in older men; 5) To test whether sleep disorders are associated with bone density and fracture risk in older men. We will also supplement the bank of MrOS specimens to allow for testing of future hypotheses concerning the role of sleep in the development of age-related diseases and conditions. This application is for Case Western Reserve University to serve as a central PSG Reading Center for the proposed study. In this capacity, we will: a. Provide centralized training for aspects of MrOS related to the performance and interpretation of sleep studies. b. Provide ongoing technical support to the clinical sites for the performance of sleep studies; c. Provide timely review (for quality and medical alerts) and scoring of all records, generating reports needed for participant feedback and data analysis; d. Participate in on-going quality assurance efforts to maintain high levels of scoring accuracy and reliability; e. Develop, implement and monitor the technical performance of PSGs at the clinical field sites.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL070839-03
Application #
6898350
Study Section
Clinical Trials Review Committee (CLTR)
Program Officer
Twery, Michael
Project Start
2003-09-01
Project End
2008-06-30
Budget Start
2005-07-01
Budget End
2006-06-30
Support Year
3
Fiscal Year
2005
Total Cost
$281,641
Indirect Cost
Name
Case Western Reserve University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Eurelings, Lisa Sm; van Dalen, Jan Willem; Ter Riet, Gerben et al. (2018) Apathy and depressive symptoms in older people and incident myocardial infarction, stroke, and mortality: a systematic review and meta-analysis of individual participant data. Clin Epidemiol 10:363-379
Chen, Han; Cade, Brian E; Gleason, Kevin J et al. (2018) Multiethnic Meta-Analysis Identifies RAI1 as a Possible Obstructive Sleep Apnea-related Quantitative Trait Locus in Men. Am J Respir Cell Mol Biol 58:391-401
Rogers-Soeder, Tara S; Blackwell, Terri; Yaffe, Kristine et al. (2018) Rest-Activity Rhythms and Cognitive Decline in Older Men: The Osteoporotic Fractures in Men Sleep Study. J Am Geriatr Soc 66:2136-2143
Adabag, Selcuk; Vo, Tien N; Langsetmo, Lisa et al. (2018) Frailty as a Risk Factor for Cardiovascular Versus Noncardiovascular Mortality in Older Men: Results From the MrOS Sleep (Outcomes of Sleep Disorders in Older Men) Study. J Am Heart Assoc 7:
Tranah, Gregory J; Yaffe, Kristine; Nievergelt, Caroline M et al. (2018) APOE?4 and slow wave sleep in older adults. PLoS One 13:e0191281
Wallace, Meredith L; Stone, Katie; Smagula, Stephen F et al. (2018) Which Sleep Health Characteristics Predict All-Cause Mortality in Older Men? An Application of Flexible Multivariable Approaches. Sleep 41:
Schousboe, John T; Kats, Allyson M; Langsetmo, Lisa et al. (2018) Central Obesity and Visceral Adipose Tissue Are Not Associated With Incident Atherosclerotic Cardiovascular Disease Events in Older Men. J Am Heart Assoc 7:e009172
Leng, Yue; Goldman, Samuel M; Cawthon, Peggy M et al. (2018) Excessive daytime sleepiness, objective napping and 11-year risk of Parkinson's disease in older men. Int J Epidemiol 47:1679-1686
Rogers, Tara S; Harrison, Stephanie; Swanson, Christine et al. (2017) Rest-activity circadian rhythms and bone mineral density in elderly men. Bone Rep 7:156-163
Winkelman, John W; Blackwell, Terri; Stone, Katie et al. (2017) Associations of Incident Cardiovascular Events With Restless Legs Syndrome and Periodic Leg Movements of Sleep in Older Men, for the Outcomes of Sleep Disorders in Older Men Study (MrOS Sleep Study). Sleep 40:

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