One major, yet poorly understood cardiovascular health risk that occurs in as many as ~24% of males and 9% of females within the United States population is obstructive sleep apnea (OSA). OSA can participate in both the initiation and progression of several cardiovascular diseases including sudden death, hypertension, arrhythmias, myocardial ischemia and stroke. Treatment of OSA is primarily continuous positive airway pressure (CPAP), and while this treatment is marginally effective in reducing elevated arterial pressure (~2 mmHg) CPAP is intrusive, poorly tolerated and often discontinued despite the risks of OSA. Recent work has suggested activity in neurons within the paraventricular nucleus of the hypothalamus (PVN) that are critical for the cardiovascular responses to challenges such as stress and dehydration are not impaired, but rather possess augmented activity in models of OSA and are involved in the maintenance and/or generation of OSA induced hypertension. However the PVN is a heterogeneous nucleus. Whereas vasopressin (AVP) neurons in the PVN are sympathoexcitatory, and activation of vasopressin receptors inhibits cardioprotective parasympathetic cardiac vagal neurons (CVNs), recent work has provided exciting new evidence that the neuropeptide oxytocin, released from a different population of PVN neurons, is cardioprotective. Oxytocin reduces the adverse cardiovascular consequences of anxiety and stress and, as this study will test, perhaps the deleterious consequences of chronic nocturnal intermittent hypoxia/hypercapnia. This project challenges the paradigm that the PVN is solely sympathoexcitatory, and will test that there are two contrasting pathways from the PVN, one that co-releases oxytocin, activates CVNs and is cardioprotective, and another pathway in which vasopressin inhibits CVNs and increases adverse cardiovascular changes. Furthermore this work will test if these pathways are altered and if these two populations of PVN neurons can be differentially controlled to mitigate or enhance the adverse cardiovascular changes that occur in a model of OSA. This project will address major gaps in our knowledge and hopefully constitute a foundation for appraising new potential treatments and targets for patients with cardiovascular diseases including OSA.
This work will test if there are two contrasting pathways from the hypothalamus to parasympathetic cardiac neurons that control heart rate, and if these pathways are altered in a model of a prevalent cardiovascular disease, obstructive sleep apnea (OSA). This work seeks to identify promising targets to restore cardiac vagal activity and reduce adverse cardiovascular changes that occur in diseases such as OSA.
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|Wan, Ruiqian; Weigand, Letitia A; Bateman, Ryan et al. (2014) Evidence that BDNF regulates heart rate by a mechanism involving increased brainstem parasympathetic neuron excitability. J Neurochem 129:573-80|
|Dergacheva, Olga; Weigand, Letitia A; Dyavanapalli, Jhansi et al. (2014) Function and modulation of premotor brainstem parasympathetic cardiac neurons that control heart rate by hypoxia-, sleep-, and sleep-related diseases including obstructive sleep apnea. Prog Brain Res 212:39-58|
|Piñol, Ramón A; Jameson, Heather; Popratiloff, Anastas et al. (2014) Visualization of oxytocin release that mediates paired pulse facilitation in hypothalamic pathways to brainstem autonomic neurons. PLoS One 9:e112138|
|Dyavanapalli, Jhansi; Jameson, Heather; Dergacheva, Olga et al. (2014) Chronic intermittent hypoxia-hypercapnia blunts heart rate responses and alters neurotransmission to cardiac vagal neurons. J Physiol 592:2799-811|
|Dergacheva, Olga; Dyavanapalli, Jhansi; Piñol, Ramón A et al. (2014) Chronic intermittent hypoxia and hypercapnia inhibit the hypothalamic paraventricular nucleus neurotransmission to parasympathetic cardiac neurons in the brain stem. Hypertension 64:597-603|
|Sharp, Douglas B; Wang, Xin; Mendelowitz, David (2014) Dexmedetomidine decreases inhibitory but not excitatory neurotransmission to cardiac vagal neurons in the nucleus ambiguus. Brain Res 1574:1-5|
|Woerman, Amanda L; Mendelowitz, David (2013) Perinatal sulfur dioxide exposure alters brainstem parasympathetic control of heart rate. Cardiovasc Res 99:16-23|
|Dyavanapalli, J; Byrne, P; Mendelowitz, D (2013) Activation of D2-like dopamine receptors inhibits GABA and glycinergic neurotransmission to pre-motor cardiac vagal neurons in the nucleus ambiguus. Neuroscience 247:213-26|
|Woerman, Amanda L; Mendelowitz, David (2013) Postnatal sulfur dioxide exposure reversibly alters parasympathetic regulation of heart rate. Hypertension 62:274-80|
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