Pediatric asthma is a substantial cause of morbidity in children. Much of this morbidity is preventable as it can be directly attributable to lack of adherence to medical regimens. The consequence of non-adherence for most patients is exacerbations. Inhaled corticosteroids offer considerable protection against asthma exacerbations. However, very few children take their medications as recommended by the National Asthma Education and Prevention Program Guidelines. Therefore, adherence to medication is essential for ultimate reductions in morbidity. Asthma morbidity is higher in inner-city, low-income, minority children and adherence may be even more problematic in this group. To reach inner-city, low-income, minority children, the school provides a logical access point. Many types of school-based self-management and educational interventions have been developed and tested. While these programs have shown improvements in knowledge and self-management behaviors, they have had only a minimal impact on asthma morbidity. Therefore, we propose to develop a school based supervised asthma therapy intervention to increase adherence to medication in low-income, minority children with asthma from an inner-city pediatric asthma clinic. We will use a randomized clinical trial of 250 children from an inner-city clinic to test the impact of school based supervised asthma therapy on asthma exacerbations. Our long-term collaborative relationships and current work within our city school systems provide a strong foundation for this proposal. ? ?

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL075043-02
Application #
6888519
Study Section
Special Emphasis Panel (ZRG1-RPHB-3 (01))
Program Officer
Smith, Robert A
Project Start
2004-05-01
Project End
2007-04-30
Budget Start
2005-05-01
Budget End
2006-04-30
Support Year
2
Fiscal Year
2005
Total Cost
$724,884
Indirect Cost
Name
University of Alabama Birmingham
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
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Gerald, Lynn B; McClure, Leslie A; Mangan, Joan M et al. (2009) Increasing adherence to inhaled steroid therapy among schoolchildren: randomized, controlled trial of school-based supervised asthma therapy. Pediatrics 123:466-74
Grad, Roni; McClure, Leslie; Zhang, Sijon et al. (2009) Peak flow measurements in children with asthma: what happens at school? J Asthma 46:535-40
McClure, Leslie A; Harrington, Kathy F; Graham, Holli et al. (2008) Internet-based monitoring of asthma symptoms, peak flow meter readings, and absence data in a school-based clinical trial. Clin Trials 5:31-7
Gerald, Lynn B; McClure, Leslie Ain; Harrington, Kathy F et al. (2008) Design of the supervised asthma therapy study: implementing an adherence intervention in urban elementary schools. Contemp Clin Trials 29:304-10
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