Peripheral arterial disease (PAD) is a major cause of disability in the United States. Despite the high prevalence of this disease, conventional evaluation of patients with this condition often lacks the sensitivity and specificity needed to make therapeutic decisions or to monitor potentially new treatment options such as stem-cell transplantation and angiogenic agents.
The aims of this project are to develop and evaluate new magnetic resonance imaging (MRI) methods for the improved assessment of peripheral arterial disease (PAD). The potential impact of this work is significant as it could lead to a new and improved noninvasive examination of this disease. This project will focus on the following areas: 1) three-dimensional (3D) blood- vessel imaging of the leg without the need for contrast agent injection, and 2) time-resolved 3D dynamic contrast-enhanced imaging of the lower leg for regional blood perfusion information. Substantial technical studies in these areas to develop and optimize the MRI methods will be followed by a pilot evaluative study on patients with PAD.

Public Health Relevance

There is a need for new and improved methods to assess peripheral arterial disease (PAD), a major source of disability in the United States. Magnetic resonance imaging (MRI) is a flexible and noninvasive modality that offers the potential to provide information to help diagnose and monitor patients with this disease. This research will develop, optimize, and evaluate new MRI methods designed for patients with PAD.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Project (R01)
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Clinical and Integrative Cardiovascular Sciences Study Section (CICS)
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Reid, Diane M
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Stanford University
Engineering (All Types)
Schools of Engineering
United States
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Kwon, Kie Tae; Kerr, Adam B; Wu, Holden H et al. (2015) Non-contrast-enhanced peripheral angiography using a sliding interleaved cylinder acquisition. Magn Reson Med 74:727-38
Ingle, R Reeve; Santos, Juan M; Overall, William R et al. (2015) Self-gated fat-suppressed cardiac cine MRI. Magn Reson Med 73:1764-74
Ingle, R Reeve; Wu, Holden H; Addy, Nii Okai et al. (2014) Nonrigid autofocus motion correction for coronary MR angiography with a 3D cones trajectory. Magn Reson Med 72:347-61
Kwon, Kie Tae; Wu, Holden H; Shin, Taehoon et al. (2014) Three-dimensional magnetization-prepared imaging using a concentric cylinders trajectory. Magn Reson Med 71:1700-10
Shin, Taehoon; Worters, Pauline W; Hu, Bob S et al. (2013) Non-contrast-enhanced renal and abdominal MR angiography using velocity-selective inversion preparation. Magn Reson Med 69:1268-75
Dong, Hattie Z; Worters, Pauline W; Wu, Holden H et al. (2013) Noncontrast-enhanced renal angiography using multiple inversion recovery and alternating TR balanced steady-state free precession. Magn Reson Med 70:527-36
Quist, Brady; Hargreaves, Brian A; Cukur, Tolga et al. (2012) Simultaneous fat suppression and band reduction with large-angle multiple-acquisition balanced steady-state free precession. Magn Reson Med 67:1004-12
Cukur, Tolga; Lustig, Michael; Saritas, Emine U et al. (2011) Signal compensation and compressed sensing for magnetization-prepared MR angiography. IEEE Trans Med Imaging 30:1017-27
Cukur, Tolga; Shimakawa, Ann; Yu, Huanzhou et al. (2011) Magnetization-prepared IDEAL bSSFP: a flow-independent technique for noncontrast-enhanced peripheral angiography. J Magn Reson Imaging 33:931-9
Barral, Joelle K; Gudmundson, Erik; Stikov, Nikola et al. (2010) A robust methodology for in vivo T1 mapping. Magn Reson Med 64:1057-67

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