? The overall goal of this project is to develop new technology: a working prototype catheter whose tip is remotely magnetically deflectable for use in the endovascular interventional MR environment. Several other goals are subsidiary to this, including: the development of catheter materials which are safe and compatible with the MR environment, the development of a plasma vapor deposition and laser photolithography technique which will allow reproducible synthesis of catheters tipped with copper coils in three orthogonal axes, the development of passive or active methods for visualizing the catheter tip, three dimensional navigation of the prototype catheter in vitro in vascular phantoms within a clinical MR scanner, and measurement of heating within the catheter and surrounding simulated vasculature. If successful, the prototype created in this project would be reproducible and behave predictably under a given set of conditions. ? ?

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
1R01HL076486-01
Application #
6764826
Study Section
Diagnostic Imaging Study Section (DMG)
Program Officer
Baldwin, Tim
Project Start
2004-05-01
Project End
2007-04-30
Budget Start
2004-05-01
Budget End
2005-04-30
Support Year
1
Fiscal Year
2004
Total Cost
$475,107
Indirect Cost
Name
University of California San Francisco
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Sincic, Ryan S; Caton, Curtis J; Lillaney, Prasheel et al. (2014) System architecture for a magnetically guided endovascular microcatheter. Biomed Microdevices 16:97-106
Wilson, Mark W; Martin, Alastair B; Lillaney, Prasheel et al. (2013) Magnetic catheter manipulation in the interventional MR imaging environment. J Vasc Interv Radiol 24:885-91
Hetts, Steven W; Saeed, Maythem; Martin, Alastair et al. (2013) Magnetically-Assisted Remote Controlled Microcatheter Tip Deflection under Magnetic Resonance Imaging. J Vis Exp :
Hetts, S W; Saeed, M; Martin, A J et al. (2013) Endovascular catheter for magnetic navigation under MR imaging guidance: evaluation of safety in vivo at 1.5T. AJNR Am J Neuroradiol 34:2083-91
Settecase, Fabio; Hetts, Steven W; Martin, Alastair J et al. (2011) RF Heating of MRI-Assisted Catheter Steering Coils for Interventional MRI. Acad Radiol 18:277-85
Bernhardt, Anthony; Wilson, Mark W; Settecase, Fabio et al. (2011) Steerable catheter microcoils for interventional MRI reducing resistive heating. Acad Radiol 18:270-6