Program Director/Principal Investigator (Last, First, Middle): Psaty, BPUCG M. PROJECT SUMMARY (See instructions): The population in the US is aging. Data are sparce on cardiovascular disease in older adults, especially the oldest old, who are expected to number 18 million by 2050. The age at first myocardial infarction .(Ml) is increasing substantially, now to about age 71, and most of the cardiovascular disease (CVD) deaths in the US occur in older individuals. CVD is the single most important cost of medical care in the US. In the early 1990s, the Cardiovascular Health Study (CHS), an NHLBI-funded cohort study of risk factors for coronary heart disease (CHD) and stroke in adults 65 years or older, recruited 5888 participants, who underwent extensive examinations at baseline and annually until 1999. Examinations included traditional risk factors as well as measures of subclinical disease. Since 1990, CHS has made major contributions to the understanding of CVD in older individuals, including the risks associated with subclinical disease, inflammation, diabetes, hypertension and renal disease. In 2008, CHS has the unique opportunity of evaluating clinical CHD in the oldest old--MI, angina, heart failure (HF), atrial fibrillation-and their contributions to both morbidity and mortality. In this competing continuation, the primary aim is to evaluate the incidence and determinants of cardiovascular disease and health in 1964 surviving participants aged 80 or older. The incidence of CVD in the oldest old will be related to demographic variables;measures of disability, physical functioning, and cognitive function;measures of subclinical disease;and traditional and novel clinical risk factors as well as their change over time. The data collection proposed in this application will increase the number of events in those 80 years and older by about 50% to 75% for stroke, CHD and HF. Power for assessing associations with stroke, CHD and HF is increased by 15 to 30%. The continued assessment of cardiovascular events is essential to identify determinants of successful cardiovascular aging among the oldest old.

Public Health Relevance

Relevance to public health: Additional knowledge about the determinants of cardiovascular health and disease in older adults will help physicians and their patients make diagnostic, prognostic, and therapeutic decisions. PROJECT/

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL080295-09
Application #
8586338
Study Section
Cardiovascular and Sleep Epidemiology (CASE)
Program Officer
Olson, Jean
Project Start
2005-09-05
Project End
2014-11-30
Budget Start
2013-12-01
Budget End
2014-11-30
Support Year
9
Fiscal Year
2014
Total Cost
$1,157,079
Indirect Cost
$134,489
Name
University of Washington
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Carbone, Laura D; B?žková, Petra; Fink, Howard A et al. (2017) Association of Plasma SDF-1 with Bone Mineral Density, Body Composition, and Hip Fractures in Older Adults: The Cardiovascular Health Study. Calcif Tissue Int 100:599-608
Li, Changwei; Kim, Yun Kyoung; Dorajoo, Rajkumar et al. (2017) Genome-Wide Association Study Meta-Analysis of Long-Term Average Blood Pressure in East Asians. Circ Cardiovasc Genet 10:e001527
Zillikens, M Carola; Demissie, Serkalem; Hsu, Yi-Hsiang et al. (2017) Large meta-analysis of genome-wide association studies identifies five loci for lean body mass. Nat Commun 8:80
Wallace, E R; Siscovick, D S; Sitlani, C M et al. (2017) Incident atrial fibrillation and the risk of fracture in the cardiovascular health study. Osteoporos Int 28:719-725
Mehta, Tapan; Buzkova, Petra; Kizer, Jorge R et al. (2017) Higher plasma transforming growth factor (TGF)-? is associated with kidney disease in older community dwelling adults. BMC Nephrol 18:98
Nowak, Kristen L; Bartz, Traci M; Dalrymple, Lorien et al. (2017) Fibroblast Growth Factor 23 and the Risk of Infection-Related Hospitalization in Older Adults. J Am Soc Nephrol 28:1239-1246
Steenstrup, Troels; Kark, Jeremy D; Verhulst, Simon et al. (2017) Telomeres and the natural lifespan limit in humans. Aging (Albany NY) 9:1130-1142
Carbone, L D; B?žková, P; Fink, H A et al. (2017) Association of DPP-4 activity with BMD, body composition, and incident hip fracture: the Cardiovascular Health Study. Osteoporos Int 28:1631-1640
Holzinger, Emily R; Verma, Shefali S; Moore, Carrie B et al. (2017) Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals. BioData Min 10:25
Baumgartner, Christine; da Costa, Bruno R; Collet, Tinh-Hai et al. (2017) Thyroid Function Within the Normal Range, Subclinical Hypothyroidism, and the Risk of Atrial Fibrillation. Circulation 136:2100-2116

Showing the most recent 10 out of 368 publications