During 1997-99, the INTERMAP Study - with NHLBI support - surveyed 4,680 men and women ages 40-59 from 17 diverse population samples in Japan (4 samples), the Peoples Republic of China (PRC) (3 samples), the UK (2 samples), and the USA (8 samples). With standardized, quality-controlled methods, 4 24-hour dietary recalls, 2 timed 24-hour urine collections, 8 blood pressure (BP) measurements, anthropometric, and questionnaire data (on sociodemographic and biomedical traits) were accrued for all participants. Foods, beverages, and supplements were converted to nutrients (83 total) with use of up-dated, enhanced, standardized tables on nutrient composition (4 tables, 1/country). Urines were analyzed for Na, K, Ca, Mg, creatinine, albuminuria, amino acids. A high-quality central laboratory in London, England completed nuclear magnetic resonance (NMR) spectroscopic analyses of all urine specimens (2 from each of the 4, 680 participants plus 10% randomly selected, blinded split specimens for external quality control). All data underwent extensive quality control checks and were computerized and secured at the two INTERMAP International Coordinating Centers in Chicago and London, England.
AIMS : Overall aim is - in a highly cost effective way - to add a new dimension of research information and thereby achieve a qualitative advance in knowledge on the etiopathogenesis of population-wide adverse BP levels (prehypertensive and hypertensive), i.e., develop a new epidemiologic area based on the urinary metabolic products whereby multiple dietary and diet-related factors influence BP. Based on the vast, unique array of high quality BP, nutritional, urinary metabolite, etc. data available and accruable, the specific aims are to identify and quantify - from NMR spectra in hand plus mass spectrometry and other techniques - urinary metabolites discriminatively related to BP and to each of several dietary (vegetable protein, soy protein, arachidonic acid, Na/K), diet-related sociodemographic (education, ethnicity) and anthropometric (body mass index) factors impacting BP. Advanced bioinformatics techniques and biochemical methods are to be used to address each aim. SIGNIFICANCE: The BP problem is population-wide;waiting for individuals to develop hypertension and then treating them with drugs is an inadequate strategy. This study - by identifying specific urinary metabolites implicated in the etiologic pathways whereby adverse dietary/lifestyle patterns lead to population-wide adverse BP levels - can help create fully effective strategies for prevention/eradication of the mass BP problem.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL084228-03
Application #
7564669
Study Section
Cardiovascular and Sleep Epidemiology (CASE)
Program Officer
Loria, Catherine
Project Start
2007-02-01
Project End
2011-01-31
Budget Start
2009-02-01
Budget End
2010-01-31
Support Year
3
Fiscal Year
2009
Total Cost
$525,212
Indirect Cost
Name
Northwestern University at Chicago
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Stamler, Jeremiah; Chan, Queenie; Daviglus, Martha L et al. (2018) Relation of Dietary Sodium (Salt) to Blood Pressure and Its Possible Modulation by Other Dietary Factors: The INTERMAP Study. Hypertension 71:631-637
Posma, Joram M; Garcia-Perez, Isabel; Ebbels, Timothy M D et al. (2018) Optimized Phenotypic Biomarker Discovery and Confounder Elimination via Covariate-Adjusted Projection to Latent Structures from Metabolic Spectroscopy Data. J Proteome Res 17:1586-1595
Chekmeneva, Elena; Dos Santos Correia, Gonçalo; Gómez-Romero, María et al. (2018) Ultra-Performance Liquid Chromatography-High-Resolution Mass Spectrometry and Direct Infusion-High-Resolution Mass Spectrometry for Combined Exploratory and Targeted Metabolic Profiling of Human Urine. J Proteome Res 17:3492-3502
Aljuraiban, Ghadeer S; Stamler, Jeremiah; Chan, Queenie et al. (2018) Relations between dairy product intake and blood pressure: the INTERnational study on MAcro/micronutrients and blood Pressure. J Hypertens 36:2049-2058
Chan, Queenie; Loo, Ruey Leng; Ebbels, Timothy M D et al. (2017) Metabolic phenotyping for discovery of urinary biomarkers of diet, xenobiotics and blood pressure in the INTERMAP Study: an overview. Hypertens Res 40:336-345
Chekmeneva, Elena; Dos Santos Correia, Gonçalo; Chan, Queenie et al. (2017) Optimization and Application of Direct Infusion Nanoelectrospray HRMS Method for Large-Scale Urinary Metabolic Phenotyping in Molecular Epidemiology. J Proteome Res 16:1646-1658
Oude Griep, Linda M; Seferidi, Paraskevi; Stamler, Jeremiah et al. (2016) Relation of unprocessed, processed red meat and poultry consumption to blood pressure in East Asian and Western adults. J Hypertens 34:1721-9
Chan, Queenie; Stamler, Jeremiah; Griep, Linda M Oude et al. (2016) An Update on Nutrients and Blood Pressure. J Atheroscler Thromb 23:276-89
Aljuraiban, Ghadeer S; Griep, Linda M Oude; Griep, Linda M O et al. (2015) Total, insoluble and soluble dietary fibre intake in relation to blood pressure: the INTERMAP Study. Br J Nutr 114:1480-6
Elliott, Paul; Posma, Joram M; Chan, Queenie et al. (2015) Urinary metabolic signatures of human adiposity. Sci Transl Med 7:285ra62

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