The broad, long-term objectives of this application are to provide evidence about the potential health benefits of regular aerobic exercise in overweight children, who are therefore at increased risk for nonalcoholic fatty liver disease and atherosclerosis.
The specific aims will examine the cross-sectional associations of liver injury (including liver fat, visceral fat, inflammation, and fibrosis) with risk for atherosclerosis (arterial stiffness) and other cardiovascular risk factors, and will test the effect of an after-school exercise program on these measures. This is a revision (i.e. competitive supplement) to add these measures to an ongoing project, R01 HL087923, which is testing the effect of the exercise program on cognitive outcomes. Therefore, this project may be performed sooner and at significantly lower cost as a supplement than as a separate project.

Public Health Relevance

An unexpectedly high prevalence of nonalcoholic fatty liver disease has recently been documented in overweight children. This is a serious health condition which can lead to liver failure and cardiovascular disease, such as atherosclerosis. Weight loss can improve this condition, but little is known about the specific effects of exercise. This project will examine the links between liver health and risk for atherosclerosis in overweight and obese children, and will test the effect of a long-term after-school exercise program.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
3R01HL087923-02S1
Application #
7880457
Study Section
Psychosocial Risk and Disease Prevention Study Section (PRDP)
Program Officer
Stoney, Catherine
Project Start
2008-09-05
Project End
2013-07-31
Budget Start
2010-07-15
Budget End
2010-07-31
Support Year
2
Fiscal Year
2010
Total Cost
$247,351
Indirect Cost
Name
Georgia Regents University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
966668691
City
Augusta
State
GA
Country
United States
Zip Code
30912
Stojek, Monika M K; Montoya, Amanda K; Drescher, Christopher F et al. (2017) Fitness, Sleep-Disordered Breathing, Symptoms of Depression, and Cognition in Inactive Overweight Children: Mediation Models. Public Health Rep 132:65S-73S
Kindler, Joseph M; Pollock, Norman K; Ross, Hannah L et al. (2017) Obese Versus Normal-Weight Late-Adolescent Females have Inferior Trabecular Bone Microarchitecture: A Pilot Case-Control Study. Calcif Tissue Int 101:479-488
Bustamante, Eduardo Esteban; Davis, Catherine Lucy; Frazier, Stacy Lynn et al. (2016) Randomized Controlled Trial of Exercise for ADHD and Disruptive Behavior Disorders. Med Sci Sports Exerc 48:1397-407
Davis, Catherine L; Tingen, Martha S; Jia, Jenny et al. (2016) Passive Smoke Exposure and Its Effects on Cognition, Sleep, and Health Outcomes in Overweight and Obese Children. Child Obes 12:119-25
Schwarz, Nicolette F; Krafft, Cynthia E; Chi, Lingxi et al. (2015) Antisaccade-related brain activation in children with attention-deficit/hyperactivity disorder--A pilot study. Psychiatry Res 234:272-9
Davis, Catherine L; Tkacz, Joseph P; Tomporowski, Phillip D et al. (2015) Independent Associations of Organized Physical Activity and Weight Status with Children's Cognitive Functioning: A Matched-Pairs Design. Pediatr Exerc Sci 27:477-87
Pollock, Norman K (2015) Childhood obesity, bone development, and cardiometabolic risk factors. Mol Cell Endocrinol 410:52-63
Zhang, Jing; Li, Xiang; Li, Cong et al. (2014) Inferring functional interaction and transition patterns via dynamic Bayesian variable partition models. Hum Brain Mapp 35:3314-31
Krafft, Cynthia E; Schaeffer, David J; Schwarz, Nicolette F et al. (2014) Improved frontoparietal white matter integrity in overweight children is associated with attendance at an after-school exercise program. Dev Neurosci 36:1-9
Chen, Mo; Han, Junwei; Hu, Xintao et al. (2014) Survey of encoding and decoding of visual stimulus via FMRI: an image analysis perspective. Brain Imaging Behav 8:7-23

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