Obesity contributes to cardiovascular disease, type 2 diabetes, liver disease and increases risk for many other serious health conditions throughout life. Over the past 3 decades, obesity rates have risen dramatically accompanied by significant health disparities. In the U.S., lower-income and minority groups are at greatest risk. Since the determinants of obesity are multifactorial, multidisciplinary research is essential to consider biological, behavioral, and social determinants and their interactions. The proposed project continues to be one of the most comprehensive longitudinal studies of risk for, and consequences of, obesity, with data on growth, social circumstances, psychological functioning, sleep and physical health from infancy to adulthood. It will involve 1100 Chileans at 22 y who participated in research related to nutrition, growth and development as infants, with follow up at 5, 10, and 16 y (with adolescent data on eating behavior, fat mass, and cardiovascular risk). Participants were born during a dramatic nutritional transition, resulting in obesity prevalence rising twice as fast as it did in the U.S. At 16 y, 37.7% were over-weight or obese, with 6% in the extreme obesity range. The continuation focuses on a sensitive period for obesity, the transition to adulthood. We will determine how the following processes influence the development of obesity and related health risks: biological and social factors in infancy and childhood (Aim 1);development of health behaviors (sleep, physical activity and eating behavior) from adolescence to young adulthood (Aim 2);and mechanisms relating sleep to obesity (Aim 3).
For Aim 1, we will continue our ongoing approach to understanding how early life factors (e.g., infancy weight gain, breastfeeding, parent characteristics, and social circumstance) relate to obesity and health risks. We expect that risks from early life will be modified by educational trajectories, work experience, and social relationships during the transition to adulthood.
For Aim 2, we will assess continuity and change in health behaviors and how they relate to obesity, cardiovascular and metabolic risk.
For Aim 3, we continue our research on the biological mechanisms relating sleep to obesity, with polysomnographic recordings in 40 overweight/obese young adults and 40 normal weight controls. Because of the study's longitudinal nature, we are positioned to unravel important questions about the direction of effects between sleep and obesity. We will also study biological and behavioral responses to sleep restriction in another subset of obese and normal weight participants (n = 80). We will assess hormonal responses, followed by 4 days of monitoring for physical activity, eating behavior and sleep. Our study is exceptional in the depth and breadth of longitudinal data from infancy to the transition to adulthood, with objective data on health behaviors in adolescence and adulthood. The study remains at the forefront of understanding the complex interactions between biology, social factors, and health behaviors as they relate to fat mass and risk for heart disease, insulin resistance, and liver disease.

Public Health Relevance

Obesity, one of the foremost public health problems in the world, leads to heart disease, diabetes, some cancers and other diseases. This research investigates how biological factors and social conditions influence the development of sleep and physical activity patterns, eating behaviors and ultimately obesity. This study will assess such effects in a sample of over 1100 young adults.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
2R01HL088530-06
Application #
8639308
Study Section
Kidney, Nutrition, Obesity and Diabetes Study Section (KNOD)
Program Officer
Aviles-Santa, Larissa
Project Start
2007-04-01
Project End
2018-06-30
Budget Start
2014-09-01
Budget End
2015-06-30
Support Year
6
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Pediatrics
Type
Schools of Medicine
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92093
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Burrows, Raquel; Correa-Burrows, Paulina; Reyes, Marcela et al. (2016) High cardiometabolic risk in healthy Chilean adolescents: associations with anthropometric, biological and lifestyle factors. Public Health Nutr 19:486-93
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Lee, July; East, Patricia; Blanco, Estela et al. (2016) Parenthood linked to new onset overweight or obesity among Chilean adolescents. Int J Adolesc Med Health 28:225-7
Wang, Helen; Blanco, Estela; Algarín, Cecilia et al. (2016) Weight Status and Physical Activity: Combined Influence on Cardiometabolic Risk Factors Among Adolescents, Santiago, Chile. Glob Pediatr Health 3:2333794X16674561
Correa-Burrows, Paulina; Burrows, Raquel; Blanco, Estela et al. (2016) Nutritional quality of diet and academic performance in Chilean students. Bull World Health Organ 94:185-92
Martinez, Suzanna M; Castillo, Marcela; Lozoff, Betsy et al. (2015) Socioeconomic Status and Internalizing Symptoms in Chilean Children: Does Reserve Capacity Matter? J Child Adolesc Behav 3:
Reyes, Marcela; Quintanilla, Cristina; Burrows, Raquel et al. (2015) Obesity is associated with acute inflammation in a sample of adolescents. Pediatr Diabetes 16:109-16
Burrows, R; Correa-Burrows, P; Reyes, M et al. (2015) Healthy Chilean Adolescents with HOMA-IR ≥ 2.6 Have Increased Cardiometabolic Risk: Association with Genetic, Biological, and Environmental Factors. J Diabetes Res 2015:783296
Martinez, Suzanna M; Blanco, Estela; Delva, Jorge et al. (2014) Perception of neighborhood crime and drugs increases cardiometabolic risk in Chilean adolescents. J Adolesc Health 54:718-23

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