- """"""""Genome-wide association studies of adiposity in Samoans"""""""" The goal of this new application is to define the genetic variation that underlies obesity and obesity-related phenotypes among adult Samoans. We will use genome-wide association methods to take advantage of newer more powerful techniques to identify single nucleotide polymorphism (SNP) variants that are associated with adiposity phenotypes. We will conduct these studies using a population sample of 2,500 adults from rural areas of Samoa, an independent nation experiencing the nutritional transition. We will replicate the findings from our genome-wide association studies of important SNPs by further analysis in three different study samples: an independent sample of 2,500 Samoans from earlier studies in American Samoa and Samoa, and 1,500 adults from Croatia and 1,000 adults from China. We will then determine the sequences of the important genes and determine the specific genetic variants in the sequenced genes that are associated with obesity in these three samples. Finally, we will explore gene-environment interactions, taking advantage of identified genetic variants in the sequenced regions and the substantial environmental heterogeneity in lifestyle and nutritional behaviors within Samoa. The knowledge gained from this research will aid the development of interventions on obesity among Samoans including those in the US and may be generalizable to other Pacific Islander groups.

Public Health Relevance

The goal of this application is to define the genetic variation that underlies obesity and obesity-related phenotypes among adult Samoans using genome-wide association methods. Genotyping will be performed using a panel of approximately 900,000 SNPs, and adiposity phenotypes will be collected from 2,500 adult Samoans residing in rural regions of Samoa.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL093093-04
Application #
8402646
Study Section
Kidney, Nutrition, Obesity and Diabetes (KNOD)
Program Officer
Papanicolaou, George
Project Start
2009-09-01
Project End
2014-12-31
Budget Start
2013-01-01
Budget End
2013-12-31
Support Year
4
Fiscal Year
2013
Total Cost
$736,846
Indirect Cost
$40,660
Name
Brown University
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
001785542
City
Providence
State
RI
Country
United States
Zip Code
02912
Maredia, Hasina; Lambert-Messerlian, Geralyn M; Palomaki, Glenn E et al. (2016) Cut-off levels for hyperandrogenemia among Samoan women: An improved methodology for deriving normative data in an obese population. Clin Biochem 49:782-6
Minster, Ryan L; Hawley, Nicola L; Su, Chi-Ting et al. (2016) A thrifty variant in CREBRF strongly influences body mass index in Samoans. Nat Genet 48:1049-54
Hawley, Nicola L; Minster, Ryan L; Weeks, Daniel E et al. (2014) Prevalence of adiposity and associated cardiometabolic risk factors in the Samoan genome-wide association study. Am J Hum Biol 26:491-501
Hawley, N L; Johnson, W; Nu'usolia, O et al. (2014) The contribution of feeding mode to obesogenic growth trajectories in American Samoan infants. Pediatr Obes 9:e1-e13
Buhule, Olive D; Minster, Ryan L; Hawley, Nicola L et al. (2014) Stratified randomization controls better for batch effects in 450K methylation analysis: a cautionary tale. Front Genet 5:354
Seiden, Andrew; Hawley, Nicola L; Schulz, Dirk et al. (2012) Long-term trends in food availability, food prices, and obesity in Samoa. Am J Hum Biol 24:286-95
Hawley, Nicola L; Wier, Lauren M; Cash, Haley L et al. (2012) Modernization and cardiometabolic risk in Samoan adolescents. Am J Hum Biol 24:551-7
Karns, Rebekah; Viali, Satupaitea; Tuitele, John et al. (2012) Common variants in FTO are not significantly associated with obesity-related phenotypes among Samoans of Polynesia. Ann Hum Genet 76:17-24
McGarvey, Stephen T (2012) Epigenetics, and human biology and health responses to modernization in the Samoan archipelago. Coll Antropol 36:1169-73
Cash, Haley L; McGarvey, Stephen T; Houseman, E Andrés et al. (2011) Cardiovascular disease risk factors and DNA methylation at the LINE-1 repeat region in peripheral blood from Samoan Islanders. Epigenetics 6:1257-64

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