Hypertension is a disease of unknown etiology. Most investigators agree that retention of excess sodium (Na) underlies the sustained increase in blood pressure (BP) that characterizes hypertension. In children, BP elevation accompanies somatic growth in height and weight. While BP is known to be correlated to various somatic measurements, physiological mechanisms that underlie the observed associations remain unclear. Additionally, few investigations have examined whether any characteristics of somatic growth relate to the rise of BP or to the early onset of pre-hypertension or hypertension. Our preliminary data strongly suggest that the process of somatic growth is well synchronized with that of BP development. With the compelling data evidence, we propose to conduct an epidemiological study to delineate the relations among somatic growth, Na retention, and BP using data from an existing cohort of children. We hypothesize that a strong relationship of somatic growth with BP during the period of pubertal growth is mediated at least partially by increases in retention of Na. Along this line, we will examine the effects of somatic changes on measures of Na retention, and the effects of somatic growth characteristics on post-pubertal BP and the onset of pre- hypertension and hypertension. The study addresses some of the critically important but previously unanswered questions about the mechanisms of BP change during puberty. The hypotheses are derived from strong and compelling preliminary data evidence. If successfully carried out, the research may uncover early risk factors for hypertension, affording opportunities of timely interventions. To assess the post-pubertal BP and onset of pre-hypertension and hypertension, we seek to extend the follow-up period for 350 subjects in the cohort for five additional years till the subjects become adults. The existing cohort and the new extension will afford a rare opportunity to assess the linkage between somatic growth patterns in puberty and post-pubertal BP, with accommodation of Na retention. To implement, we have proposed an integrated analytical plan. By focusing on the beginnings of hypertension, before BP reaches hypertensive levels, this research provides a new approach for investigating mechanisms. While scientifically significant, the study is also cost effective because it fully utilizes the existing longitudinal data.

Public Health Relevance

This study uses longitudinal data to examine the effects of pubertal growth and sodium retention on post-pubertal blood pressure. The research may provide crucial insight on the physiological mechanisms that underlie the elevation of blood pressure. Its public health relevance is that it may facilitate the identification of somatic growth patterns that signal future risk of hypertension.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL095086-04
Application #
8208160
Study Section
Clinical and Integrative Cardiovascular Sciences Study Section (CICS)
Program Officer
OH, Youngsuk
Project Start
2009-01-01
Project End
2013-12-31
Budget Start
2012-01-01
Budget End
2013-12-31
Support Year
4
Fiscal Year
2012
Total Cost
$381,150
Indirect Cost
$133,650
Name
Indiana University-Purdue University at Indianapolis
Department
Biostatistics & Other Math Sci
Type
Schools of Medicine
DUNS #
603007902
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Tu, Wanzhu; Eckert, George J; Hannon, Tamara S et al. (2014) Racial differences in sensitivity of blood pressure to aldosterone. Hypertension 63:1212-8
Tu, Wanzhu; Pratt, J Howard (2013) A consideration of genetic mechanisms behind the development of hypertension in blacks. Curr Hypertens Rep 15:108-13
Yu, Zhangsheng; Eckert, George J; Liu, Hai et al. (2013) Adiposity has unique influence on the renin-aldosterone axis and blood pressure in black children. J Pediatr 163:1317-22.e1
Watson, S E; Li, Z; Tu, W et al. (2013) Obstructive sleep apnoea in obese adolescents and cardiometabolic risk markers. Pediatr Obes :
Tu, Wanzhu; Eckert, George J; DiMeglio, Linda A et al. (2011) Intensified effect of adiposity on blood pressure in overweight and obese children. Hypertension 58:818-24
Jung, Jeesun; Basile, David P; Pratt, J Howard (2011) Sodium reabsorption in the thick ascending limb in relation to blood pressure: a clinical perspective. Hypertension 57:873-9
Hancock 2nd, Michael L; Bichet, Daniel G; Eckert, George J et al. (2010) Race, sex, and the regulation of urine osmolality: observations made during water deprivation. Am J Physiol Regul Integr Comp Physiol 299:R977-80
Jung, Jeesun; Zhao, Yiqiang (2010) Allelic based gene-gene interaction in case-control studies. Hum Hered 69:14-27
Aljadhey, Hisham; Tu, Wanzhu; Hansen, Richard A et al. (2010) Risk of hyperkalemia associated with selective COX-2 inhibitors. Pharmacoepidemiol Drug Saf 19:1194-8
Tu, Wanzhu; Eckert, George J; Saha, Chandan et al. (2009) Synchronization of adolescent blood pressure and pubertal somatic growth. J Clin Endocrinol Metab 94:5019-22