The broad, long-term objective of this proposal is to improve the prognosis of patients with arterial disease, one of the leading causes of death in the United States. Contrast-enhanced imaging is the clinically accepted conventional method for MRA. However, patients with renal insufficiency who receive gadolinium- based agents are at risk for developing a debilitating and a potentially fatal disease known as nephrogenic systemic fibrosis. The purpose of the proposed project is to develop a new non-contrast-enhanced MRA technique. Two sets of ECG-triggered, cardiac phase-resolved 3D images will be acquired with and without flow sensitized dephasing (FSD) preparation, respectively. In systole, steady state free precession (SSFP) imaging generates bright blood signals for both arteries and veins, independent of flow, while images acquired with FSD preparation show black blood arteries and bright blood veins because FSD preparation causes dramatic signal loss to fast flowing arterial blood but has little effect on slow flowing venous blood and background tissue. Subtraction of the two image sets will show arteries only. The """"""""black-blood"""""""" images can also be used for arterial wall evaluation to quantify plaque burden. Therefore, this technique has the potential for simultaneous MRA and arterial wall imaging of the entire body.
Specific aims of the project are: (1) To develop the cardiac phase-resolved, FSD-prepared, self-gated 3D SSFP technique for simultaneous MRA and arterial wall imaging. Four tasks will be performed: (a) A self-gating method will be developed to eliminate potential image artifacts due to motion (e.g., swallowing during carotid MRA and respiratory motion for renal MRA). (b) SSFP will be improved for consistent bright blood MRA in the presence of flow. (c) FSD preparation and data acquisition schemes will be optimized to maximize contrast to noise ratio between arterial blood and background/vein for MRA and vessel wall imaging in carotid, renal, and peripheral arteries. (d) k-t parallel imaging will be optimized to improve the speed of cardiac phase-resolved MRA and vessel wall imaging. (2) To verify that the non-contrast MRA and vessel wall imaging technique can accurately depict artery stenoses and quantify plaque burden in patients. Three groups of patients with carotid, renal, and peripheral artery disease, respectively, will be studied. Contrast-enhanced MRA and single-slice turbo spin echo techniques will be used as the reference methods for MRA and wall imaging, respectively. The end point of the project is the development and initial clinical validation of a new non-contrast- enhanced MRA approach capable of simultaneous MRA and arterial wall imaging of the entire body.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Project (R01)
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Medical Imaging Study Section (MEDI)
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Evans, Frank
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Cedars-Sinai Medical Center
Los Angeles
United States
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Fan, Zhaoyang; Yang, Qi; Deng, Zixin et al. (2017) Whole-brain intracranial vessel wall imaging at 3 Tesla using cerebrospinal fluid-attenuated T1-weighted 3D turbo spin echo. Magn Reson Med 77:1142-1150
Wang, Wanqian; Yang, Qi; Li, Debiao et al. (2017) Incremental Value of Plaque Enhancement in Patients with Moderate or Severe Basilar Artery Stenosis: 3.0?T High-Resolution Magnetic Resonance Study. Biomed Res Int 2017:4281629
Yang, Qi; Deng, Zixin; Bi, Xiaoming et al. (2017) Whole-brain vessel wall MRI: A parameter tune-up solution to improve the scan efficiency of three-dimensional variable flip-angle turbo spin-echo. J Magn Reson Imaging 46:751-757
Xie, Guoxi; Zhang, Nan; Xie, Yibin et al. (2016) DANTE-prepared three-dimensional FLASH: A fast isotropic-resolution MR approach to morphological evaluation of the peripheral arterial wall at 3 Tesla. J Magn Reson Imaging 43:343-51
Zhang, Nan; Fan, Zhaoyang; Luo, Nan et al. (2016) Noncontrast MR angiography (MRA) of infragenual arteries using flow-sensitive dephasing (FSD)-prepared steady-state free precession (SSFP) at 3.0 Tesla: Comparison with contrast-enhanced MRA. J Magn Reson Imaging 43:364-72
Yang, Qi; Duan, Jiangang; Fan, Zhaoyang et al. (2016) Early Detection and Quantification of Cerebral Venous Thrombosis by Magnetic Resonance Black-Blood Thrombus Imaging. Stroke 47:404-9
Xie, Yibin; Yang, Qi; Xie, Guoxi et al. (2016) Improved black-blood imaging using DANTE-SPACE for simultaneous carotid and intracranial vessel wall evaluation. Magn Reson Med 75:2286-94
LaBounty, T M; Hardy, W D; Fan, Z et al. (2016) Carotid artery thickness is associated with chronic use of highly active antiretroviral therapy in patients infected with human immunodeficiency virus: A 3.0 Tesla magnetic resonance imaging study. HIV Med 17:516-23
Xie, Yibin; Fan, Zhaoyang; Saouaf, Rola et al. (2015) Adaptive online self-gating (ADIOS) for free-breathing noncontrast renal MR angiography. Magn Reson Med 73:312-7
Fan, Zhaoyang; Yu, Wei; Xie, Yibin et al. (2014) Multi-contrast atherosclerosis characterization (MATCH) of carotid plaque with a single 5-min scan: technical development and clinical feasibility. J Cardiovasc Magn Reson 16:53

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