Cardiovascular disease (CVD) is the leading cause of death in the United States, but African Americans bear a disproportionate burden from CVD. The reasons why African Americans are unusually susceptible to CVD and its complications are complex, multifactorial, and incompletely understood. Standard risk factors and subclinical atherosclerotic disease severity do not fully define the risk for CVD. Researchers have come to understand that vascular dysfunction contributes at both early and advanced stages in the pathogenesis of coronary heart disease and stroke. We propose to noninvasively characterize vascular function in 3,829 African Americans participants in the Jackson Heart Study by examining three related vascular phenotypes. We will measure (1) flow-mediated brachial artery dilation (FMD) and reactive hyperemia, (2) digital peripheral arterial tonometry (PAT) waveforms, and (3) aortic pulse wave velocity (PWV) and pressure flow relations. Our study includes four specific aims. We will: (1) Examine cross-sectional relations between CVD risk factors and FMD, PAT and PWV in African American adults;(2) Study the contribution of genetic variation to FMD, PAT and PWV in conduit vessels in African Americans;(3) Relate FMD, PAT and PWV to each other and to regional adiposity and to other markers of subclinical CVD;and (4) Assess the relation of FMD, PAT and PWV in conduit arteries to incident CVD events and mortality. The study will provide a novel opportunity to characterize the environmental and genetic correlates and the prognostic implications of abnormal vascular function in African Americans. By focusing on an African American cohort, the project will lead to innovative insights into health and disease in a population that is disproportionately at risk of CVD morbidity and mortality in the U.S.
Cardiovascular disease (CVD) is the leading cause of death in the United States. African Americans suffer from CVD at a higher rate than whites, and we don't fully understand the reasons for this phenomenon. This study will provide a novel opportunity to characterize the environmental and genetic correlates of abnormal vascular function in African Americans, and will potentially lead to improved prevention, risk stratification and management of CVD.
|Niiranen, Teemu J; Lyass, Asya; Larson, Martin G et al. (2017) Prevalence, Correlates, and Prognosis of Healthy Vascular Aging in a Western Community-Dwelling Cohort: The Framingham Heart Study. Hypertension 70:267-274|
|Cooper, Leroy L; Palmisano, Joseph N; Benjamin, Emelia J et al. (2016) Microvascular Function Contributes to the Relation Between Aortic Stiffness and Cardiovascular Events: The Framingham Heart Study. Circ Cardiovasc Imaging 9:|
|Zachariah, Justin P; Hwang, Susan; Hamburg, Naomi M et al. (2016) Circulating Adipokines and Vascular Function: Cross-Sectional Associations in a Community-Based Cohort. Hypertension 67:294-300|
|Cooper, Leroy L; Woodard, Todd; Sigurdsson, Sigurdur et al. (2016) Cerebrovascular Damage Mediates Relations Between Aortic Stiffness and Memory. Hypertension 67:176-82|
|Chami, Hassan A; Vasan, Ramachandran S; Larson, Martin G et al. (2016) The association between sleep-disordered breathing and aortic stiffness in a community cohort. Sleep Med 19:69-74|
|Bell, Vanessa; Mitchell, Gary F (2015) Influence of vascular function and pulsatile hemodynamics on cardiac function. Curr Hypertens Rep 17:580|
|Woodard, Todd; Sigurdsson, Sigurdur; Gotal, John D et al. (2015) Segmental kidney volumes measured by dynamic contrast-enhanced magnetic resonance imaging and their association with CKD in older people. Am J Kidney Dis 65:41-8|
|Bell, Vanessa; Sigurdsson, Sigurdur; Westenberg, Jos J M et al. (2015) Relations between aortic stiffness and left ventricular structure and function in older participants in the Age, Gene/Environment Susceptibility--Reykjavik Study. Circ Cardiovasc Imaging 8:e003039|
|Mitchell, Gary F (2015) Does Measurement of Central Blood Pressure have Treatment Consequences in the Clinical Praxis? Curr Hypertens Rep 17:66|
|Woodard, Todd; Sigurdsson, Sigurdur; Gotal, John D et al. (2015) Mediation analysis of aortic stiffness and renal microvascular function. J Am Soc Nephrol 26:1181-7|
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