Obstructive sleep apnea (OSA) occurs in 50-100% of patients with Down syndrome and can significantly cause and exacerbate medical problems in these patients. Current surgical management in these children is imperfect. There are variable surgical success rates for both first line surgery [palatine tonsillectomy and adenoidectomy (T&A)] as well as secondary surgeries performed if and when T&A fails. There is a critical need for a diagnostic modality that takes into account airway anatomy, tissue compliance, and collapsibility to be able to predict surgical outcome and improve surgical planning in these patients. Our central hypothesis is that upper airway flow-structure interaction (FSI) modeling using three-dimensional (3-D) computational simulations from dynamic MRI data can be used to predict surgical outcome for children with Down syndrome who have OSA despite previous T&A. The long-term goal is to improve surgical outcome of children with Down syndrome and OSA by creating an accurate FSI predictive model. Such a diagnostic tool would help tailor surgical procedures to be more effective as well as identify and avoid unnecessary (or unhelpful) surgical procedures. These created models then can also be adjusted and applied to other populations with OSA.
Our specific aims i nclude: 1) In children with Down syndrome with persistent OSA despite previous T&A, collect data characterizing upper airway anatomy, tissue compliance, and collapsibility;2) Generate and validate individualized dynamic FSI models for each child in specific aim 1;and 3) Using the validated dynamic computational models, predict the success of surgical treatment on children with Down syndrome who have persistent OSA despite previous T&A. This work is innovative as it uses dynamic rather than static MR imaging data and applies a unique computational model that accurately captures the unsteadiness of the flow and accounts for the interaction between the airflow and the surrounding airway flexible structures.

Public Health Relevance

The proposed research is relevant to public health because it seeks to create a diagnostic tool that will better predict the need and effectiveness of specific surgical procedures in the treatment of obstructive sleep apnea (OSA) in children with Down syndrome. Such a diagnostic tool would help tailor surgical procedures to be more effective as well as identify and avoid unnecessary (or unhelpful) surgical procedures. The creation of this diagnostic tool is important in children with Down syndrome because of the very high rate and refractory nature of OSA in these children but also the creation of the tool may also be applied and benefit other populations of children and adults with OSA, which constitutes a major health problem in the USA.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL105206-03
Application #
8323924
Study Section
Special Emphasis Panel (ZHL1-CSR-G (S1))
Program Officer
Blaisdell, Carol J
Project Start
2010-09-17
Project End
2014-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
3
Fiscal Year
2012
Total Cost
$933,382
Indirect Cost
$182,703
Name
Cincinnati Children's Hospital Medical Center
Department
Type
DUNS #
071284913
City
Cincinnati
State
OH
Country
United States
Zip Code
45229
Fleck, Robert J; Amin, Raouf S; Shott, Sally R et al. (2014) MRI sleep studies: use of positive airway pressure support in patients with severe obstructive sleep apnea. Int J Pediatr Otorhinolaryngol 78:1163-6
Chen, Jie; Gutmark, Ephraim (2014) Numerical investigation of airflow in an idealized human extra-thoracic airway: a comparison study. Biomech Model Mechanobiol 13:205-14
Nayak, Khrishna S; Fleck, Robert J (2014) Seeing sleep: dynamic imaging of upper airway collapse and collapsibility in children. IEEE Pulse 5:40-4
Fleck Jr, Robert J; Mahmoud, Mohamed; McConnell, Keith et al. (2013) An adverse effect of positive airway pressure on the upper airway documented with magnetic resonance imaging. JAMA Otolaryngol Head Neck Surg 139:636-8