Cardiovascular disease (CVD) is the leading cause of death and disability in the United States, affecting more than 81 million American adults. It is well established that risk factors such as hypertension, diabetes, and hyperlipidemia not only place individuals at risk for CVD, but also place them at risk for neurocognitive impairment and dementia. CVD risk factors have been shown to be associated with a cascade of neurophysiologic and neuroanatomic changes (e.g., narrowing of the small arteries in the subcortical regions of the brain, reduced cerebral blood flow, disruption of the blood-brain barrier), resulting in cognitive impairment and dementia. Patients with CVD risk factors who exhibit cognitive impairment without dementia (CIND) are considered to be in a transition stage between normal aging and early dementia. There is great interest in CIND because longitudinal studies have documented that such individuals are highly vulnerable to developing dementia. Exercise and diet have been shown to improve CVD risk factors and also appear particularly promising lifestyle approaches for preventing dementia. In this application, we propose a randomized clinical trial of patients with CVD risk factors who also are characterized by subjective cognitive complaints and objective evidence of neurocognitive deficits without dementia (CIND). A 2 by 2 design is proposed to examine the independent and combined effects of diet and exercise on neurocognition. Participants will be randomly assigned to 6 months of aerobic exercise, dietary modification using the DASH diet, or a combination of both exercise and diet;a fourth (control) group will receive health education but otherwise will maintain their usual dietary and activity habits. The study will aim to (a) evaluate the effectiveness of aerobic exercise and the DASH diet in improving neurocognitive functioning in patients with CVD risk factors and CIND;(b) examine possible mechanisms by which exercise and diet improve neurocognition;and (c) consider potential moderators of treatment, including subclinical CVD. These data will have important clinical significance by determining the extent to which lifestyle may improve neurocognition in patients vulnerable to neurocognitive decline and will identify key vascular and related biomarkers that may account for improved neurocognition among persons with CIND.

Public Health Relevance

Cardiovascular diseases (CVD), including heart disease and stroke, account for more than one- third of all U.S. deaths at an economic cost estimated to be more than $503 billion in 2010. Conditions such as hypertension, diabetes, and hyperlipidemia are not only risk factors for CVD, but also are risk factors for neurocognitive impairment and dementia. With more than 5 million Americans presently diagnosed with dementia and with as many as 10 million additional 'baby boomers'at risk, the prevention of dementia is a pressing public health priority as its diagnosis is expected to triple in the next 50 years.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL109219-04
Application #
8656300
Study Section
Behavioral Medicine, Interventions and Outcomes Study Section (BMIO)
Program Officer
Czajkowski, Susan
Project Start
2011-09-01
Project End
2016-04-30
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
4
Fiscal Year
2014
Total Cost
$859,333
Indirect Cost
$312,066
Name
Duke University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Vásquez, Elizabeth; Batsis, John A; Germain, Cassandra M et al. (2014) Impact of obesity and physical activity on functional outcomes in the elderly: data from NHANES 2005-2010. J Aging Health 26:1032-46
Blumenthal, James A; Smith, Patrick J; Welsh-Bohmer, Kathleen et al. (2013) Can lifestyle modification improve neurocognition? Rationale and design of the ENLIGHTEN clinical trial. Contemp Clin Trials 34:60-9