Mechanical ventilation (MV) is the primary intervention used to assist neonatal and adult acute pulmonary failure patients, however, rapid and accurate assessment of patient function during ventilation remains an ongoing challenge. A primary cause of decreased lung efficiency in MV-assisted patients is ventilation/perfusion mismatch (V/Q mismatch): a mismatch between alveolar ventilation and pulmonary perfusion (blood supply). Intervention methods exist which can help to resolve V/Q mismatch, however effective application of these would benefit from a continuous monitoring method to guide successful therapy. In patients with pulmonary shunt, lack of ventilation at the alveoli, Positive End Expiratory Pressure (PEEP) is used with MV to maximize lung volume. If not monitored, lung damaging over-distention can occur. Surfactant replacement therapy can be used in neonates to resolve lung collapse (atelectasis) and patient maneuvering can be used to assist blood redistribution in patients with dead space - ventilation without perfusion. All of these methods would benefit from knowledge of what and how much therapy to administer, and to continuously monitor V/Q responses. No non-invasive continuous real-time clinical monitoring solution currently exists. We propose to develop a noninvasive, real-time, continuous Electrical Impedance Tomography (EIT) lung function monitoring system. EIT has been studied previously, however here we identify and address the technical limitations that have prevented clinical adoption. Upon successful completion, the clinician will have access to a device that will provide a 3-D regional ventilation/perfusion (V/Q) mismatch data, a 3-D regional indicator of atelectasis, and regional perfusion data.

Public Health Relevance

Mechanical ventilation (MV) is a primary support mechanism for acute lung disease patients, both adult and neonatal. At present, there is no method for real-time noninvasive monitoring of lung recruitment and ventilation/perfusion mismatch (V/Q mismatch) at the bedside, making MV management a challenge. We propose to develop and validate a noninvasive, real-time lung function monitor that can guide therapy at the bedside, resulting in reduction of lung injury incidents and improved patient outcomes.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Project (R01)
Project #
Application #
Study Section
Biomedical Imaging Technology Study Section (BMIT)
Program Officer
Harabin, Andrea L
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
General Electric Global Research Center
United States
Zip Code
Boverman, Gregory; Isaacson, David; Newell, Jonathan C et al. (2017) Efficient Simultaneous Reconstruction of Time-Varying Images and Electrode Contact Impedances in Electrical Impedance Tomography. IEEE Trans Biomed Eng 64:795-806
Amm, Bruce; Kao, Tzu-Jen; Newell, Jonathan et al. (2016) Comparison of impedance measurements near the skin of newborns and adults. Physiol Meas 37:938-50
Muller, P A; Li, T; Isaacson, D et al. (2015) Estimating a regional ventilation-perfusion index. Physiol Meas 36:1283-95
Kao, Tzu-Jen; Amm, Bruce; Wang, Xin et al. (2014) Real-time 3D electrical impedance imaging for ventilation and perfusion of the lung in lateral decubitus position. Conf Proc IEEE Eng Med Biol Soc 2014:1135-8
Li, Taoran; Isaacson, David; Newell, Jonathan C et al. (2014) Adaptive techniques in electrical impedance tomography reconstruction. Physiol Meas 35:1111-24
Amm, Bruce; Kao, Tzu-Jen; Wang, Xin et al. (2014) Real-time 3D electrical impedance imaging for ventilation monitoring of the lung: Pilot study. Conf Proc IEEE Eng Med Biol Soc 2014:6064-7
Li, Taoran; Kao, Tzu-Jen; Isaacson, David et al. (2013) Adaptive Kaczmarz method for image reconstruction in electrical impedance tomography. Physiol Meas 34:595-608
Muller, P A; Isaacson, D; Newell, J C et al. (2013) Calderón's method on an elliptical domain. Physiol Meas 34:609-22