The current epidemic rate of childhood obesity is a leading health concern as overweight/obese youth may suffer from comorbid conditions, once considered exclusive to adults. It has been suggested that physical inactivity is a major determinant of obesity and obesity-related health risk in children and adolescents. Recent studies in adults report that the combination of aerobic and resistance exercise is a better strategy than aerobic or resistance exercise alone for reducing risk factors for type 2 diabetes. Currently, the most effective exercise modality for concurrent reductions of [adiposity], in particular abdominal fat, and risk factors for type 2 diabetes and cardiovascular disease (CVD) is unknown in adolescents. Therefore, we will employ, for the first time, a randomized controlled trial to examine the effects of a long-term aerobic exercise, resistance exercise, and a combination of both exercise regimens on: 1) in vivo insulin sensitivity, glucose tolerance and risk for type 2 diabetes;2) total adiposity, skeletal muscle mass, visceral adiposity and ectopic fat in the liver and skeletal muscle;3) traditional and non-traditional risk factors/markers for CD in overweight boys and girls. We will recruit [168] sedentary overweight (BMI >85th percentile) adolescent boys and girls aged 12-[17] years old and randomly assign them to one of four 6-month intervention groups (n = [42] each group): 1) aerobic exercise (180 min/week), 2) resistance exercise (180 min/week), 3) [combined] aerobic and resistance exercise (180 min/week) or 4) non-exercising control group. A weight maintenance diet (55-60% carbohydrate, 15-20% protein, and 25-30% fat) will be prescribed and monitored for all groups, so that any changes in energy balance will be induced by exercise intervention alone (e.g., no calorie restriction). We believe that this proposed application will have a significant implication that is directly relevant for one in three American adolescents who are at increased risk of developing obesity-related co-morbidities.

Public Health Relevance

We will examine whether a combination of aerobic and resistance exercise is a better [exercise] strategy as compared to a similar duration of either aerobic or resistance exercise alone [for reducing total and abdominal fat and obesity-related health risks] in adolescents.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
1R01HL114857-01A1
Application #
8503821
Study Section
Clinical and Integrative Cardiovascular Sciences Study Section (CICS)
Program Officer
Bonds, Denise
Project Start
2013-08-15
Project End
2018-05-31
Budget Start
2013-08-15
Budget End
2014-05-31
Support Year
1
Fiscal Year
2013
Total Cost
$1,089,979
Indirect Cost
$316,043
Name
University of Pittsburgh
Department
Pediatrics
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213