The Jackson Heart Study (JHS) was designed to collect clinical, laboratory, imaging, genetic, and environmental data that could provide insights into the determinants and development of cardiovascular and related diseases in African Americans (AA) residing in the Jackson, MS community. Between 2000 and 2012, 5301 AA men and women participated at a baseline and two additional clinic examinations. Obesity and diabetes are important contributors to cardiovascular outcomes and the overall health disparities observed between AAs and whites in the United States. Both conditions are highly prevalent among those enrolled in JHS. The overall goal of this proposal is to enhance the scientific output of the JHS with respect to obesity/diabetes and its cardiometabolic and vascular outcomes. We propose to conduct in-depth cross- sectional and longitudinal analyses of obesity and glucometabolic parameters, and select outcomes (incident diabetes, subclinical and clinical cardiovascular disease) by engaging scientists in the newly established JHS Obesity Diabetes Working Group (ODWG). The ODWG will function as a virtual team, utilizing a combination of teleconferences, in person meetings, and internet-based file sharing tools, and will include Wake Forest, JHS and other interested investigators and trainees. The investigative team includes expertise in epidemiology, biostatistics, imaging, diabetes, obesity, and cardiovascular disease. We also have an extant relationship with JHS as Wake Forest served as the reading center for the CT and MRI studies performed at exams 2 and 3. A focus of ODWG activities includes mentoring junior investigators and trainees. We also expect that analysis and dissemination of these data will spur the application for separate funding for ancillary studies.

Public Health Relevance

This research seeks to better understand obesity and diabetes in African American adults by establishing a working group to analyze obesity and diabetes-related data collected by the Jackson Heart Study in 5301 African American men and women. Through monthly conference calls and yearly in-person meetings with Jackson Heart scientists we will write papers using these data, and mentor junior faculty and trainees.

National Institute of Health (NIH)
Research Project (R01)
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Special Emphasis Panel (ZHL1)
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Harman, Jane
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Wake Forest University Health Sciences
Public Health & Prev Medicine
Schools of Medicine
United States
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Krishnamoorthy, Arun; Greiner, Melissa A; Bertoni, Alain G et al. (2016) The Obesity and Heart Failure Epidemics Among African Americans: Insights From the Jackson Heart Study. J Card Fail 22:589-97
Joseph, Joshua J; Echouffo-Tcheugui, Justin B; Kalyani, Rita R et al. (2016) Aldosterone, Renin, and Diabetes Mellitus in African Americans: The Jackson Heart Study. J Clin Endocrinol Metab 101:1770-8
Effoe, Valery S; Correa, Adolfo; Chen, Haiying et al. (2015) High-Sensitivity C-Reactive Protein Is Associated With Incident Type 2 Diabetes Among African Americans: The Jackson Heart Study. Diabetes Care 38:1694-700