We propose to combine the clinical and analytical capabilities of our group with the well-developed and rich clinical data from the Jackson Heart Study to address the risk factors and determinants of heart failure and related diseases that disproportionately affect African Americans. The overall aims of this project are: (1) to develo and facilitate a working group focused on heart failure in African Americans;(2) to characterize the etiology and development of heart failure and its relation to diabetes and chronic kidney disease;and (3) to characterize healthcare resource utilization among Medicare-eligible participants with heart failure and other major comorbid conditions.

Public Health Relevance

Heart failure disproportionately affects African Americans. A complex interplay of high blood pressure, diabetes, and chronic kidney disease likely accounts for the greater disease burden. The project's proposed examination of the burden of heart failure and its intersection with diabetes and chronic kidney disease will broadly inform policy makers, hospitals, and national leaders interested in improving prevention measures, health outcomes and quality among African Americans with heart failure.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Project (R01)
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Special Emphasis Panel (ZHL1-CSR-B (O2))
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Harman, Jane
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Duke University
Other Clinical Sciences
Schools of Medicine
United States
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Parikh, Kishan S; Greiner, Melissa A; Wang, Wei et al. (2017) Representativeness of Medicare Participants in the Jackson Heart Study for African American Medicare Beneficiaries. Epidemiology 28:740-746
Parikh, Kishan S; Greiner, Melissa A; Suzuki, Takeki et al. (2017) Resting Heart Rate and Long-term Outcomes Among the African American Population: Insights From the Jackson Heart Study. JAMA Cardiol 2:172-180
Dunlay, Shannon M; Lippmann, Steven J; Greiner, Melissa A et al. (2017) Perceived Discrimination and Cardiovascular Outcomes in Older African Americans: Insights From the Jackson Heart Study. Mayo Clin Proc 92:699-709
Foraker, Randi E; Greiner, Melissa; Sims, Mario et al. (2016) Comparison of risk scores for the prediction of stroke in African Americans: Findings from the Jackson Heart Study. Am Heart J 177:25-32
Krishnamoorthy, Arun; Greiner, Melissa A; Bertoni, Alain G et al. (2016) The Obesity and Heart Failure Epidemics Among African Americans: Insights From the Jackson Heart Study. J Card Fail 22:589-97
O'Brien, Emily C; Greiner, Melissa A; Sims, Mario et al. (2015) Depressive Symptoms and Risk of Cardiovascular Events in Blacks: Findings From the Jackson Heart Study. Circ Cardiovasc Qual Outcomes 8:552-9
Mentz, Robert J; Greiner, Melissa A; DeVore, Adam D et al. (2015) Ventricular conduction and long-term heart failure outcomes and mortality in African Americans: insights from the Jackson Heart Study. Circ Heart Fail 8:243-51