Atherosclerosis is a progressive disease that is characterized by the accumulation of lipids, cholesterol, fibrous constituents, monocytes, and various other inflammatory cells in the arterial wall. Atherosclerosis is one of the major causes of morbidity and mortality in developed countries. The major cause of deaths from heart attacks (86%) and brain aneurysm (45%) are due to vulnerable plaques that rupture suddenly and trigger a blood clot or thrombus that blocks blood flow. Early detection of plaque lesions is the first and necessary step in preventing the lethal consequences of atherosclerosis. Diagnosis of the latent vulnerability of a plaque lesion relies on both tissue structural and chemical compositions. Multimodality intravascular imaging that can provide both structure and molecular information will provide clinicians with a critically important tool for diagnosing vulnerable plaques, monitoring the progression of disease, and evaluating the efficacy of intervention. The broad, long term objective of this proposal is to develop an integrated multimodal intravascular imaging system that combines intravascular ultrasound (IVUS), optical coherence tomography (OCT), and photoacoustic tomography (PAT). The multimodal intravascular imaging system is unique in that it combines the advantages of high spatial resolution of OCT, broad imaging depth of US, and molecular contrast of PAT. The integrated IVUS/OCT/PAT will provide the physician with a powerful tool for imaging, diagnosing, and managing vulnerable plaques.
The specific aims are: (1) Develop a high-speed nanosecond fiber laser centered at 1730 nm for PAT imaging with lipid contrast; (2) Develop an integrated IVUS/OCT/PAT imaging catheter; (3) Develop a multimodality imaging system that combines IVUS/OCT/PAT; (4) Demonstrate real-time in vivo multimodality imaging of cardiovascular plaques in rabbit and porcine animal models. The proposed research requires an interdisciplinary team of scientists, engineers, and clinicians. We have assembled such a team: OCT/PAT group (Dr. Chen from BLI at UCI); IVUS/PAT group (Drs. Zhou and Shung from NIH Transducer Resource Center at USC); and Interventional cardiology group (Dr. Patel from Dept. of Cardiology at UCI). The proposed research is expected to have significant impact in the earlier detection, prevention, and treatment of cardiovascular diseases. PHS 398

Public Health Relevance

Cardiovascular disease is the number one killer in America. This proposal focuses on the development of an integrated multimodal intravascular imaging system that provides both tissue structural and molecular contrast. The proposed research is expected to have significant impact in the earlier detection, prevention, and treatment of cardiovascular diseases.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL127271-04
Application #
9467576
Study Section
Biomedical Imaging Technology Study Section (BMIT)
Program Officer
Danthi, Narasimhan
Project Start
2015-04-01
Project End
2019-03-31
Budget Start
2018-04-01
Budget End
2019-03-31
Support Year
4
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of California Irvine
Department
Biomedical Engineering
Type
Biomed Engr/Col Engr/Engr Sta
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92617
Qu, Yueqiao; Ma, Teng; He, Youmin et al. (2017) Miniature probe for mapping mechanical properties of vascular lesions using acoustic radiation force optical coherence elastography. Sci Rep 7:4731
Jing, Joseph C; Chen, Jason J; Chou, Lidek et al. (2017) Visualization and Detection of Ciliary Beating Pattern and Frequency in the Upper Airway using Phase Resolved Doppler Optical Coherence Tomography. Sci Rep 7:8522
Yu, Mingyue; Li, Yang; Ma, Teng et al. (2017) Intravascular Ultrasound Imaging With Virtual Source Synthetic Aperture Focusing and Coherence Factor Weighting. IEEE Trans Med Imaging 36:2171-2178
Zhu, Jiang; Zhang, Buyun; Qi, Li et al. (2017) Quantitative angle-insensitive flow measurement using relative standard deviation OCT. Appl Phys Lett 111:181101
Li, Yan; Jing, Joseph; Heidari, Emon et al. (2017) Intravascular Optical Coherence Tomography for Characterization of Atherosclerosis with a 1.7 Micron Swept-Source Laser. Sci Rep 7:14525
Piao, Zhonglie; Zeng, Lvming; Chen, Zhongping et al. (2016) Q-switched Erbium-doped fiber laser at 1600?nm for photoacoustic imaging application. Appl Phys Lett 108:143701
Jing, Joseph C; Chou, Lidek; Su, Erica et al. (2016) Anatomically correct visualization of the human upper airway using a high-speed long range optical coherence tomography system with an integrated positioning sensor. Sci Rep 6:39443
Zhu, Jiang; Qi, Li; Miao, Yusi et al. (2016) 3D mapping of elastic modulus using shear wave optical micro-elastography. Sci Rep 6:35499
Xu, Xiangqun; Zhu, Jiang; Chen, Zhongping (2016) Dynamic and quantitative assessment of blood coagulation using optical coherence elastography. Sci Rep 6:24294
Qu, Yueqiao; Ma, Teng; He, Youmin et al. (2016) Acoustic Radiation Force Optical Coherence Elastography of Corneal Tissue. IEEE J Sel Top Quantum Electron 22:

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