The proposed research is designed to continue the clinical evaluation of the efficacy of Dialectical Behavior Therapy (DBT) with chronically parasuicidal women with borderline personality disorder (BPD). Previous research has demonstrated the efficacy of standard DBT, which consists of concurrent individual psychotherapy and group behavioral skills training, with this patient population. What remains unclear is whether these results can be replicated under more tightly controlled conditions (e.g., guaranteeing that all subjects in the control group minimally receive psychotherapy). The proposed treatment study addresses this question and aims to accomplish the following: l) to complete our current randomized clinical trial evaluating the efficacy of one year of DBT as compared to one year of Treatment-by-Experts provided in the community (TBE); and 2) to analyze whether treatment characteristics that are theoretically linked to DBT and that are defined as DBT strategies are, in fact, predictive of treatment response. Potential confounds from previous studies of the efficacy of DBT are tightly controlled within this trial. In continuation of the current study, we will add 57 more subjects total, 28 in DBT and 29 in TBE, to bring the study to the originally-intended 60 subjects per cell. Outcome measures for this study will assess suicidal behaviors, therapy-interfering behaviors (e.g., treatment compliance), and quality of life interfering behaviors (e.g., psychiatric hospitalization, affect, social functioning, and global functioning). Subjects will be assessed at pretreatment, at 4-month intervals during the treatment year, and at 4-month intervals for one year following treatment. Additional daily patient ratings and weekly patient and therapist ratings for subjects in the DBT condition will be obtained.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
2R01MH034486-16A1
Application #
6011908
Study Section
Treatment Assessment Review Committee (TA)
Program Officer
Pearson, Jane L
Project Start
1987-01-01
Project End
2003-05-31
Budget Start
1999-09-15
Budget End
2000-05-31
Support Year
16
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Washington
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Harned, Melanie S; Lungu, Anita; Wilks, Chelsey R et al. (2017) Evaluating a Multimedia Tool for Suicide Risk Assessment and Management: The Linehan Suicide Safety Net. J Clin Psychol 73:308-318
Wilks, Chelsey R; Korslund, Kathryn E; Harned, Melanie S et al. (2016) Dialectical behavior therapy and domains of functioning over two years. Behav Res Ther 77:162-9
Linehan, Marsha M; Korslund, Kathryn E; Harned, Melanie S et al. (2015) Dialectical behavior therapy for high suicide risk in individuals with borderline personality disorder: a randomized clinical trial and component analysis. JAMA Psychiatry 72:475-82
Bedics, Jamie D; Atkins, David C; Harned, Melanie S et al. (2015) The therapeutic alliance as a predictor of outcome in dialectical behavior therapy versus nonbehavioral psychotherapy by experts for borderline personality disorder. Psychotherapy (Chic) 52:67-77
Neacsiu, Andrada D; Lungu, Anita; Harned, Melanie S et al. (2014) Impact of dialectical behavior therapy versus community treatment by experts on emotional experience, expression, and acceptance in borderline personality disorder. Behav Res Ther 53:47-54
Bedics, Jamie D; Atkins, David C; Comtois, Katherine A et al. (2012) Treatment differences in the therapeutic relationship and introject during a 2-year randomized controlled trial of dialectical behavior therapy versus nonbehavioral psychotherapy experts for borderline personality disorder. J Consult Clin Psychol 80:66-77
Harned, Melanie S; Pantalone, David W; Ward-Ciesielski, Erin F et al. (2011) The prevalence and correlates of sexual risk behaviors and sexually transmitted infections in outpatients with borderline personality disorder. J Nerv Ment Dis 199:832-8
Harned, Melanie S; Rizvi, Shireen L; Linehan, Marsha M (2010) Impact of co-occurring posttraumatic stress disorder on suicidal women with borderline personality disorder. Am J Psychiatry 167:1210-7
Harned, Melanie S; Jackson, Safia C; Comtois, Katherine A et al. (2010) Dialectical behavior therapy as a precursor to PTSD treatment for suicidal and/or self-injuring women with borderline personality disorder. J Trauma Stress 23:421-9
Neacsiu, Andrada D; Rizvi, Shireen L; Linehan, Marsha M (2010) Dialectical behavior therapy skills use as a mediator and outcome of treatment for borderline personality disorder. Behav Res Ther 48:832-9

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