The Developmental Processes in Schizophrenic Disorders project involves an ongoing series of longitudinal studies of the psychopathology and treatment of individuals with a recent onset of schizophrenia. The proposed new protocol focuses on improving the efficacy of interventions targeting work and school functioning during the early stage of schizophrenia and examining the mediators of their effects. Effective interventions for individuals in the early stage of schizophrenia are critical for preventing chronic patterns of disability and are therefore of particular public health significance. The new protocol aims to build upon the substantial gains in work and school re-entry that were achieved with the current treatment protocol using Individual Placement and Support and Workplace Fundamental Modules. Based on evidence that neurocognitive deficits and medication non-adherence are key determinants of impaired work performance, the new protocol will test whether cognitive remediation procedures, aimed at improving neurocogriition, and injectable, long-acting risperidone, aimed at increasing medication adherence, can increase work/school performance. Hypothesized mechanisms through which these treatments may influence functional outcome will be evaluated. To clarify the mediators and moderators of the impact of cognitive remediation on work/school functioning, aspects of social cognition, coping skills, learning of work skills, awareness of illness, and motivation will be examined. The study will determine whether injectable, long-acting risperidone improves medication adherence, clinical course, and work/school functioning as compared to oral risperidone. Potential predictors of response to these treatments will be evaluated. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH037705-22
Application #
7327768
Study Section
Special Emphasis Panel (ZMH1-ERB-D (06))
Program Officer
Kozak, Michael J
Project Start
1983-09-15
Project End
2010-11-30
Budget Start
2007-12-01
Budget End
2008-11-30
Support Year
22
Fiscal Year
2008
Total Cost
$658,089
Indirect Cost
Name
University of California Los Angeles
Department
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
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McCleery, Amanda; Lee, Junghee; Fiske, Alan P et al. (2016) Longitudinal stability of social cognition in schizophrenia: A 5-year follow-up of social perception and emotion processing. Schizophr Res 176:467-72
Subotnik, Kenneth L; Casaus, Laurie R; Ventura, Joseph et al. (2015) Long-Acting Injectable Risperidone for Relapse Prevention and Control of Breakthrough Symptoms After a Recent First Episode of Schizophrenia. A Randomized Clinical Trial. JAMA Psychiatry 72:822-9
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Ventura, J; Ered, A; Gretchen-Doorly, D et al. (2015) Theory of mind in the early course of schizophrenia: stability, symptom and neurocognitive correlates, and relationship with functioning. Psychol Med 45:2031-43
Ventura, Joseph; Subotnik, Kenneth L; Gitlin, Michael J et al. (2015) Negative symptoms and functioning during the first year after a recent onset of schizophrenia and 8 years later. Schizophr Res 161:407-13
Ventura, Joseph; Subotnik, Kenneth L; Ered, Arielle et al. (2014) The relationship of attitudinal beliefs to negative symptoms, neurocognition, and daily functioning in recent-onset schizophrenia. Schizophr Bull 40:1308-18
Nuechterlein, Keith H; Ventura, Joseph; Subotnik, Kenneth L et al. (2014) The early longitudinal course of cognitive deficits in schizophrenia. J Clin Psychiatry 75 Suppl 2:25-9

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