Neuropsychological (NP) testing of ethnic minority groups indicates that such groups may perform differently from the often used middle-class, white standardization groups. Currently, sensitive neuropsychological test batteries are administered to ethnically-mixed populations in an effort to expose the early existence of subtle cognitive disturbances in those diagnosed HIV-positive. Without revision, the existing NP norms will undoubtedly provide an erroneous picture of cognitive function in those minorities being tested. The extent of this error is compounded by recent findings showing a disproportionately high HIV seroprevalence in African-American and Hispanic groups. The current project has two goals. The first is to develop norms from a sample of 540 male and female African-American subjects on a broad range of neuropsychological measures commonly used to assess neurobehavioral impairment associated with HIV infection. The second goal is to compare matched white and African-American, HIV- positive and HIV-negative subjects on this battery using additional data already being collected at the San Diego HIV Neurobehavioral Research Center (HNRC). A subsample of 100 subjects will be retested after one year to answer important questions regarding normal retest performance. It is expected that comparisons will demonstrate the importance of using minority-based norms in studying neurobehavioral phenomena in HIV-infected minority groups. Specifically, comparisons of the HIV-positive African-American group with the HIV-negative white group may suggest HIV-related impairment rates that are spuriously high. It is further anticipated that actual rates of impairment in white and African-American groups will be comparable when appropriate norms are used for both groups.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH049550-03
Application #
2248963
Study Section
Psychobiological, Biological, and Neurosciences Subcommittee (MHAI)
Project Start
1993-03-01
Project End
1997-02-28
Budget Start
1995-04-01
Budget End
1996-02-29
Support Year
3
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Psychiatry
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Gonzalez, Raul; Miller, S Walden; Carey, Catherine L et al. (2006) Association between dyads and correct responses on the Paced Auditory Serial Addition Task (PASAT). Assessment 13:381-4
Gonzalez, Raul; Grant, Igor; Miller, S Walden et al. (2006) Demographically adjusted normative standards for new indices of performance on the Paced Auditory Serial Addition Task (PASAT). Clin Neuropsychol 20:396-413
Diehr, Michael C; Cherner, Mariana; Wolfson, Tanya J et al. (2003) The 50 and 100-item short forms of the Paced Auditory Serial Addition Task (PASAT): demographically corrected norms and comparisons with the full PASAT in normal and clinical samples. J Clin Exp Neuropsychol 25:571-85
Norman, M A; Evans, J D; Miller, W S et al. (2000) Demographically corrected norms for the California Verbal Learning Test. J Clin Exp Neuropsychol 22:80-94
Diehr, M C; Heaton, R K; Miller, W et al. (1998) The Paced Auditory Serial Addition Task (PASAT): norms for age, education, and ethnicity. Assessment 5:375-87