This proposal concerns interrelationships among steroid hormones and catecholamine neurotransmitters in relation to sexually dimorphic brain structures mediating the activation of a naturally occurring motivated behavior, male sexual behavior. In Japanese quail, the animal model system investigated here, testosterone is able to activate both motivational and performance components of male-typical reproductive behaviors in adult males but does not activate all aspects of the behavior in adult females. The endocrine mechanisms occurring during embryonic development that control the differentiation of this sex difference in response to testosterone are understood. This hormonal activation in adulthood requires the metabolism of testosterone to 17beta estradiol by the enzyme aromatase in the preoptic medial nucleus, a brain area that is larger in volume in males than in females. Previous work has established that estradiol acts on behavior both in a slow manner (hours to days) as well as in a fast manner (seconds to minutes) and aromatase is similarly regulated in this bimodal fashion. In the current application 14 experiments organized into 5 aims are proposed.
Aim I concerns male/female differences in the neural circuit controlling male-typical behaviors that might explain the remarkable sex difference in the ability of testosterone to activate behavior. A previously identified functional topography in the preoptic medial nucleus related to the control of motivational and performance components of male-typical behavior will be studied in both males and females and a comparison of the mechanisms controlling these two aspects of the behavior will allow us to identify neuroendocrine mechanisms specific to motivational control.
In Aim II, immediate early gene methods will be utilized to functionally analyze the sexually dimorphic circuit regulating this male-typical motivated behavior, identify the causes of the immediate early gene induction and assess its function.
In aim III, topographic variation in ascending catecholamine projections to the preoptic medial nucleus and gene expression in these cell groups, that have been previously implicated in the control of motivated behaviors, will be assessed in relation to behavioral production.
Aim I V concerns the mechanisms regulating rapid changes in the activity of aromatase in vivo and Aim V involves studies of the receptor systems and brain areas mediating the rapid effects of estrogen on behavior. These studies on the neuroendocrine control of sexual motivation provide an assay for understanding the effects of steroid hormones on sex and gender differences in the control of motivated behaviors. Such studies are essential for the development of a scientific underpinning for treatments designed to address behavioral pathologies connected to mental health. Investigations of sex differences in steroid hormone activation of motivated behaviors can also provide insight into the etiology of sexually differentiated and/or hormone- regulated psychiatric diseases. A wide variety of neurological and psychiatric syndromes, likely related to imbalances in monoaminergic neurotransmission, are more common in males, or are more common in females, suggesting that sex differences in the secretion and action of sex steroid hormones may be involved in the development and/or maintenance of these syndromes. The study of steroid hormone-neurotransmitter interactions can provide insight into the etiology of sexually differentiated or steroid-dependent diseases. Alteration in steroid hormone functioning may have major consequences on the control of affective and sexual motivated behaviors in humans and these effects are in all probability mediated by the steroid-induced alterations of neurotransmission.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH050388-20
Application #
8261394
Study Section
Neurobiology of Motivated Behavior Study Section (NMB)
Program Officer
Simmons, Janine M
Project Start
1993-07-01
Project End
2013-06-30
Budget Start
2012-05-01
Budget End
2013-06-30
Support Year
20
Fiscal Year
2012
Total Cost
$309,870
Indirect Cost
$79,200
Name
Johns Hopkins University
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Caro, Samuel P; Balthazart, Jacques; Bonadonna, Francesco (2015) The perfume of reproduction in birds: chemosignaling in avian social life. Horm Behav 68:25-42
Iyilikci, Onur; Baxter, Samantha; Balthazart, Jacques et al. (2014) Fos expression in monoaminergic cell groups in response to sociosexual interactions in male and female Japanese quail. Behav Neurosci 128:48-60
Cornil, Charlotte A; Schmit, Melanie; de Bournonville, Catherine et al. (2014) Age-dependent and age-independent effects of testosterone in male quail. Gen Comp Endocrinol 208:64-72
Dickens, M J; de Bournonville, C; Balthazart, J et al. (2014) Relationships between rapid changes in local aromatase activity and estradiol concentrations in male and female quail brain. Horm Behav 65:154-64
Charlier, Thierry D; Seredynski, Aurore L; Niessen, Neville-Andrew et al. (2013) Modulation of testosterone-dependent male sexual behavior and the associated neuroplasticity. Gen Comp Endocrinol 190:24-33
Mouriec, Karen; Balthazart, Jacques (2013) Peripubertal proliferation of progenitor cells in the preoptic area of Japanese quail (Coturnix japonica). Brain Res 1516:20-32
Dickens, M J; Cornil, C A; Balthazart, J (2013) Neurochemical control of rapid stress-induced changes in brain aromatase activity. J Neuroendocrinol 25:329-39
Niessen, Neville-Andrew; Balthazart, Jacques; Ball, Gregory F et al. (2013) C-fos down-regulation inhibits testosterone-dependent male sexual behavior and the associated learning. Eur J Neurosci 38:3325-37
Balthazart, Jacques; de Meaultsart, Celine Corbisier; Ball, Gregory F et al. (2013) Distinct neuroendocrine mechanisms control neural activity underlying sex differences in sexual motivation and performance. Eur J Neurosci 37:735-42
Seredynski, Aurore L; Balthazart, Jacques; Christophe, Virginie J et al. (2013) Neuroestrogens rapidly regulate sexual motivation but not performance. J Neurosci 33:164-74

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