Psychopathologists have increasingly applied experimental cognitive psychology paradigms to elucidate automatic information-processing biases associated with panic disorder. The theoretical motivation for targeting automaticity arises from the """"""""ego-dystonic"""""""" phenomenology of panic; panic attacks appear involuntary, thereby implying that the underlying mechanisms are automatic, not strategic (i.e., involuntary, conscious, effortful). Although extant anxiety research has been incapable of distinguishing between automatic and strategic processing, recent breakthroughs in cognitive science now provide approaches for isolating automaticity. The purpose of the four experiments proposed here is to apply these methods to determine whether panic disorder is characterized by 1) automatic attentional biases for processing threat cues, 2) deficits in strategic control over attentional biases for threat, and 3) memory biases for threat. These methods include Jacoby's (1991) process- dissociation procedures, a hybrid paradigm incorporating elements of repetition priming and word naming, and a hybrid paradigm incorporating elements of repetition priming and Stroop color-naming. Control groups of normal subjects, social phobia patients, and major depressive disorder patients will reveal whether predicted cognitive biases are specific to panic disorder or whether they occur in other emotional disorders. Control stimuli of positive valence will reveal whether predicted biases are specific to information about threat or whether they extend to any emotional information. Determination of automatic attentional and memory biases for threat ought to clarify what cognitive dysfunctions figure in the maintenance of panic disorder.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH051927-02
Application #
2251416
Study Section
Clinical Psychopathology Review Committee (CPP)
Project Start
1994-09-30
Project End
1997-08-31
Budget Start
1995-09-01
Budget End
1996-08-31
Support Year
2
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Harvard University
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
071723621
City
Cambridge
State
MA
Country
United States
Zip Code
02138
McNally, R J; Otto, M W; Hornig, C D (2001) The voice of emotional memory: content-filtered speech in panic disorder, social phobia, and major depressive disorder. Behav Res Ther 39:1329-37
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McNally, R J (1999) EMDR and Mesmerism: a comparative historical analysis. J Anxiety Disord 13:225-36
McNally, R J (1998) Experimental approaches to cognitive abnormality in posttraumatic stress disorder. Clin Psychol Rev 18:971-82
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McNally, R J; Hornig, C D; Otto, M W et al. (1997) Selective encoding of threat in panic disorder: application of a dual priming paradigm. Behav Res Ther 35:543-9
McNally, R J; Eke, M (1996) Anxiety sensitivity, suffocation fear, and breath-holding duration as predictors of response to carbon dioxide challenge. J Abnorm Psychol 105:146-9
Eke, M; McNally, R J (1996) Anxiety sensitivity, suffocation fear, trait anxiety, and breath-holding duration as predictors of response to carbon dioxide challenge. Behav Res Ther 34:603-7
Wilhelm, S; McNally, R J; Baer, L et al. (1996) Directed forgetting in obsessive-compulsive disorder. Behav Res Ther 34:633-41

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