Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
7R01MH055309-03
Application #
2675447
Study Section
Psychobiology, Behavior, and Neuroscience Review Committee (PBN)
Project Start
1996-05-01
Project End
2000-04-30
Budget Start
1997-11-01
Budget End
1998-04-30
Support Year
3
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Psychiatry
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Aston-Jones, Gary; Cohen, Jonathan D (2005) Adaptive gain and the role of the locus coeruleus-norepinephrine system in optimal performance. J Comp Neurol 493:99-110
Aston-Jones, Gary; Cohen, Jonathan D (2005) An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance. Annu Rev Neurosci 28:403-50
Rajkowski, Janusz; Majczynski, Henryk; Clayton, Edwin et al. (2004) Activation of monkey locus coeruleus neurons varies with difficulty and performance in a target detection task. J Neurophysiol 92:361-71
Clayton, Edwin C; Rajkowski, Janusz; Cohen, Jonathan D et al. (2004) Phasic activation of monkey locus ceruleus neurons by simple decisions in a forced-choice task. J Neurosci 24:9914-20
Aston-Jones, G; Rajkowski, J; Cohen, J (2000) Locus coeruleus and regulation of behavioral flexibility and attention. Prog Brain Res 126:165-82
Aston-Jones, G; Rajkowski, J; Cohen, J (1999) Role of locus coeruleus in attention and behavioral flexibility. Biol Psychiatry 46:1309-20
Aston-Jones, G; Rajkowski, J; Ivanova, S et al. (1998) Neuromodulation and cognitive performance: recent studies of noradrenergic locus ceruleus neurons in behaving monkeys. Adv Pharmacol 42:755-9
Aston-Jones, G; Rajkowski, J; Kubiak, P (1997) Conditioned responses of monkey locus coeruleus neurons anticipate acquisition of discriminative behavior in a vigilance task. Neuroscience 80:697-715
Aston-Jones, G; Rajkowski, J; Kubiak, P et al. (1996) Role of the locus coeruleus in emotional activation. Prog Brain Res 107:379-402