Abstract

The major goal of the proposed project is to identify the gene (or genes) predisposing to schizophrenia in the geographically isolated population of Palau, Micronesia. Four large extended pedigrees containing 22, 16, 20, and 20 ascertained cases of schizophrenia will be genotyped with the latest, high density Cooperative Human Linkage Center (CHLC) genome-wide screening set of DNA markers. Linkage analyses will be subjected to linkage disequilibrium analyses using all available pedigrees, including simplex families. Candidate genes mapping to a region of linkage or linkage disequilibrium may be analyzed using mutation scanning techniques. The applicant claims that identification of a disease-predisposing mutation will have implications for the etiology, diagnosis, pathogenesis, and treatment of schizophrenia.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH056098-02
Application #
2416189
Study Section
Epidemiology and Genetics Review Committee (EPI)
Project Start
1996-08-01
Project End
2001-04-30
Budget Start
1997-05-01
Budget End
1998-04-30
Support Year
2
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
University of Utah
Department
Psychiatry
Type
Schools of Medicine
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112

  Publications

Lewis, Cathryn M; Levinson, Douglas F; Wise, Lesley H et al. (2003) Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia. Am J Hum Genet 73:34-48
Devlin, B; Bacanu, S-A; Roeder, K et al. (2002) Genome-wide multipoint linkage analyses of multiplex schizophrenia pedigrees from the oceanic nation of Palau. Mol Psychiatry 7:689-94
Devlin, B; Roeder, K; Otto, C et al. (2001) Genome-wide distribution of linkage disequilibrium in the population of Palau and its implications for gene flow in Remote Oceania. Hum Genet 108:521-8
Bennett, P J; Hoff, M; Rosenthal, J et al. (2000) Mutation screening of a neutral amino acid transporter, ASCT1, and its potential role in schizophrenia. Psychiatr Genet 10:79-82
Myles-Worsley, M; Coon, H; Tiobech, J et al. (1999) Genetic epidemiological study of schizophrenia in Palau, Micronesia: prevalence and familiality. Am J Med Genet 88:4-10
Lind, B; Hoff, M; Rosenthal, J et al. (1998) Analysis of chromosome 6 markers in eight Utah schizophrenia pedigrees. Psychiatr Genet 8:171-3
Coon, H; Myles-Worsley, M; Tiobech, J et al. (1998) Evidence for a chromosome 2p13-14 schizophrenia susceptibility locus in families from Palau, Micronesia. Mol Psychiatry 3:521-7