The present study is a continuation into adulthood of a major longitudinal twin study of aggression and antisocial behavior (ASB) and its social and biological risk factors (#MH58354) in a diverse urban sample. The first two funding periods provided comprehensive laboratory assessments of behavioral, neurocognitive, social and psychophysiological function, and multi-trait, multi-rater assessments of externalizing psychopathology during four waves of investigation when the twins were ages 9-10 (Wave 1) 11-13 (Wave 2), 14-16 (Wave 3) and 17-18 years old (Wave 4). Relationships of ASB with known risk factors (social and biological) were confirmed, and new relationships identified. The extent to which genetic and environmental factors affect ASB, its risk factors and their relationships has also been elucidated, with many findings shown to vary across gender, informant, definition of ASB, and age. We propose to extend the study to include an adult assessment at ages 19-23 (Wave 5), to obtain comprehensive measures of antisocial and aggressive behavior and their risk factors during a period of greatest risk for criminal offending, antisocial personality disorder and substance abuse. The primary aim of the next phase is to understand environmental, genetic, and phenotypic continuities in externalizing behavior problems and their biological and social risk factors through adulthood, including the prediction of adult outcomes from childhood and adolescent measures. Adding the adult assessment will yield the most comprehensive, prospective longitudinal data on externalizing behavior problems ever obtained in a genetically informative design. This five-wave, 15 year longitudinal twin study will provide the unique opportunity to understand how genes and environment combine and interact to produce antisocial outcomes from childhood to adulthood, and will greatly enhance our understanding of externalizing psychopathology and its heterogeneous developmental trajectories. Understanding gene-environment interplay in the development of externalizing psychopathology is of key importance to future intervention and prevention.

Public Health Relevance

Continuation of this longitudinal twin study into adulthood will provide the unique opportunity to unravel the developmental course of externalizing behavior problems across several critical periods of the lifespan, including childhood, adolescence, and ultimately young adulthood. Understanding the development of externalizing problems and their underlying mechanisms will enable prediction of adult psychopathology from early childhood, and provide opportunities to identify protective factors and thus effective prevention of seriously deviant and maladaptive behavior during adulthood. Given the costs of antisocial behavior-including criminal offending, substance use, and psychopathy--to both individuals and society, the reduction of these behaviors will provide enormous benefits to public health.)

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH058354-13
Application #
8502363
Study Section
Behavioral Genetics and Epidemiology Study Section (BGES)
Program Officer
Zehr, Julia L
Project Start
2000-01-05
Project End
2014-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
13
Fiscal Year
2013
Total Cost
$689,727
Indirect Cost
$269,162
Name
University of Southern California
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
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Jelenkovic, Aline; Sund, Reijo; Hur, Yoon-Mi et al. (2016) Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts. Sci Rep 6:28496
Tuvblad, Catherine; Dhamija, Devika; Berntsen, Leslie et al. (2016) Cross-Cultural Validation of the Reactive-Proactive Aggression Questionnaire (RPQ) Using Four Large Samples from the US, Hong Kong, and China. J Psychopathol Behav Assess 38:48-55
Jackson, Nicholas J; Isen, Joshua D; Khoddam, Rubin et al. (2016) Impact of adolescent marijuana use on intelligence: Results from two longitudinal twin studies. Proc Natl Acad Sci U S A 113:E500-8

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