This project investigates the interaction between reward and cognition. There is evidence that the prefrontal cortex and basal ganglia work together to support reinforcement-based decision-making, and that psychoses may result from dysregulation of this circuitry. However, we know little about the physiological mechanisms through which brainstem reward systems might contribute to abstract thought. We plan to address this by recording activity in prefrontal cortex and striatum during a categorical decision-making task. The central question addressed by this proposal is "How does knowledge about reward affect the representation of sensory evidence and decision criteria in the brain?" One process that contributes to flexible decision-making is stimulus categorization. Categorization affords a flexible linkage between sensory stimuli and motor responses. Categorization improves the efficiency of decision-making because responses that are appropriate for one member of a class often generalize to other stimuli in the same category. Categorization requires that attention be directed to critical stimulus features that identify stimuli as being in the same or different classes. Some categories are innate or overlearned. But in many cases category boundaries must shift "on the fly" to adapt to changes in the environment. We will present preliminary evidence that a fronto-striatal network is involved in categorical decision-making. In this project, we will investigate how reinforcement modulates activity in this network during categorical decision-making and category learning. This work is highly relevant to many Psychiatric and Neurological disorders including Schizophrenia, Depression, Autism, Drug Addiction, Obsessive-Compulsive disorders, and Attention-deficit disorders (ADD and ADHD).

Public Health Relevance

To function adaptively in the real world, animals and humans must constantly make choices that affect survival, reproduction, and the overall health and well-being of the organism. In this project, we will investigate how decision-outcomes modulate activity in fronto-striatal networks during categorical decision-making and category learning. This work is highly relevant to many Psychiatric and Neurological disorders including Schizophrenia, Depression, Autism, Drug Addiction, Obsessive-Compulsive disorders, and Attention-deficit disorders (ADD and ADHD).

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH059244-15
Application #
8617095
Study Section
Cognitive Neuroscience Study Section (COG)
Program Officer
Rossi, Andrew
Project Start
1998-12-01
Project End
2015-01-31
Budget Start
2014-02-01
Budget End
2015-01-31
Support Year
15
Fiscal Year
2014
Total Cost
$398,475
Indirect Cost
$150,975
Name
Columbia University
Department
Neurosciences
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Teichert, Tobias; Yu, Dian; Ferrera, Vincent P (2014) Performance monitoring in monkey frontal eye field. J Neurosci 34:1657-71
Yanike, Marianna; Ferrera, Vincent P (2014) Representation of outcome risk and action in the anterior caudate nucleus. J Neurosci 34:3279-90
Marquet, Fabrice; Tung, Yao-Sheng; Teichert, Tobias et al. (2011) Noninvasive, transient and selective blood-brain barrier opening in non-human primates in vivo. PLoS One 6:e22598
Ferrera, Vincent P; Barborica, Andrei (2010) Internally generated error signals in monkey frontal eye field during an inferred motion task. J Neurosci 30:11612-23
Ferrera, Vincent P; Yanike, Marianna; Cassanello, Carlos (2009) Frontal eye field neurons signal changes in decision criteria. Nat Neurosci 12:1458-62
Cassanello, Carlos R; Nihalani, Abhay T; Ferrera, Vincent P (2008) Neuronal responses to moving targets in monkey frontal eye fields. J Neurophysiol 100:1544-56
Xiao, Quan; Barborica, Andrei; Ferrera, Vincent P (2007) Modulation of visual responses in macaque frontal eye field during covert tracking of invisible targets. Cereb Cortex 17:918-28
Cassanello, Carlos R; Ferrera, Vincent P (2007) Computing vector differences using a gain field-like mechanism in monkey frontal eye field. J Physiol 582:647-64
Cassanello, Carlos R; Ferrera, Vincent P (2007) Visual remapping by vector subtraction: analysis of multiplicative gain field models. Neural Comput 19:2353-86
Case, Gilbert R; Ferrera, Vincent P (2007) Coordination of smooth pursuit and saccade target selection in monkeys. J Neurophysiol 98:2206-14

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