This revised application is a request for competitive renewal of a prospective, longitudinal study of the emergence of autism in infant siblings of children with autism (AU sibs) and low risk controls (tested at 6 months, 14, 24 and 36 months). Data from the existing R01 show that autism is present by 14 months, with the phenotype being characterized by deficits in social, communication, and repetitive and stereotyped patterns of behavior and interest. Symptoms become more severe in about over a third of the toddlers with ASD. In the renewal, there will be four groups of participants: (1) younger siblings of children with autism;(2) low-risk controls;(3) verbal probands through whom the younger siblings were ascertained;and (4) children with Specific Language Impairment (SLI) who will have the exact same assessment protocol at the same ages as groups 1-3 (Dr. Mabel Rice's sample from University of Kansas).
The specific aims of the proposed continuation are to follow these children until they are 6 to 8 years of age in order to: (1) examine early school-age 'outcomes'of children who manifested autism spectrum disorder (ASD), language impairment, or no impairment during toddlerhood;(2) identify 14-month-old predictors of school-age ASD and the broader autism phenotype (BAP);and (3) determine whether the language impairment associated with the BAP and ASD overlap with, and are distinguished from, SLI in predicted ways between 4 and 8 years of age. Likewise, whether autism-related social deficits are associated with SLI will be examined. Assessments will measure IQ, adaptive functioning, language (phonological, morphosyntactic, vocabulary, pragmatics), reading, social, developmental psychopathology, and autism symptoms. There is complete overlap of data for the all sites. Data will be collected at yearly intervals. Analyses will involve the use of regression models, and growth curve analysis. This will be the first study of its kind to follow children at high risk for autism and related disorders from infancy to school age, and the first to prospectively and longitudinally compare linguistic functioning in autism, the BAP, and SLI.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH059630-10
Application #
8005038
Study Section
Child Psychopathology and Developmental Disabilities Study Section (CPDD)
Program Officer
Gilotty, Lisa
Project Start
2001-09-25
Project End
2012-08-31
Budget Start
2011-01-01
Budget End
2012-08-31
Support Year
10
Fiscal Year
2011
Total Cost
$738,922
Indirect Cost
Name
Hugo W. Moser Research Institute Kennedy Krieger
Department
Type
DUNS #
155342439
City
Baltimore
State
MD
Country
United States
Zip Code
21205
Landa, Rebecca J; Haworth, Joshua L; Nebel, Mary Beth (2016) Ready, Set, Go! Low Anticipatory Response during a Dyadic Task in Infants at High Familial Risk for Autism. Front Psychol 7:721
Messinger, Daniel S; Young, Gregory S; Webb, Sara Jane et al. (2016) Commentary: sex difference differences? A reply to Constantino. Mol Autism 7:31
Szatmari, Peter; Chawarska, Katarzyna; Dawson, Geraldine et al. (2016) Prospective Longitudinal Studies of Infant Siblings of Children With Autism: Lessons Learned and Future Directions. J Am Acad Child Adolesc Psychiatry 55:179-87
Ozonoff, Sally; Young, Gregory S; Landa, Rebecca J et al. (2015) Diagnostic stability in young children at risk for autism spectrum disorder: a baby siblings research consortium study. J Child Psychol Psychiatry 56:988-98
Libertus, Klaus; Sheperd, Kelly A; Ross, Samuel W et al. (2014) Limited fine motor and grasping skills in 6-month-old infants at high risk for autism. Child Dev 85:2218-31
Chawarska, Katarzyna; Shic, Frederick; Macari, Suzanne et al. (2014) 18-month predictors of later outcomes in younger siblings of children with autism spectrum disorder: a baby siblings research consortium study. J Am Acad Child Adolesc Psychiatry 53:1317-1327.e1
Libertus, Klaus; Landa, Rebecca J (2014) Scaffolded reaching experiences encourage grasping activity in infants at high risk for autism. Front Psychol 5:1071
Rao, Patricia A; Landa, Rebecca J (2014) Association between severity of behavioral phenotype and comorbid attention deficit hyperactivity disorder symptoms in children with autism spectrum disorders. Autism 18:272-80
Zwaigenbaum, Lonnie; Young, Gregory S; Stone, Wendy L et al. (2014) Early head growth in infants at risk of autism: a baby siblings research consortium study. J Am Acad Child Adolesc Psychiatry 53:1053-62
Landa, Rebecca J; Gross, Alden L; Stuart, Elizabeth A et al. (2013) Developmental trajectories in children with and without autism spectrum disorders: the first 3 years. Child Dev 84:429-42

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