This is the competing renewal application of MH059689, proposing to continue to follow the SWAN Mental Health cohort that was recruited in 1996 through postmenopause. The women are participants in the Pittsburgh site of a multisite longitudinal study of menopause and aging, Study of Women's Health across the Nation (SWAN). Our current sample consists of 352 African American and Caucasian women, aged 52-62 years old. Women are interviewed annually with the Structured Clinical Interview (SCID) for DSM-IV Axis I Disorders. In the proposed continuation, we seek to (1) fully address our primary original aim that women will be more likely to develop a first onset or recurrence of major or minor depression during the menopausal transition than before, (2) identify the multiple risk and protective factors associated with varying patterns of the course of depression over 12 years, specifically, (a) no major or minor depression, (b) minor episodes only, (c) a single episode of major depression, and (d) recurrent or persistent depression;and (3) explore whether African American women compared to White women will have higher rates of a first onset or recurrent major or minor depression and a more persistent course of depression across the menopausal transition and after. To achieve these objectives, we will continue to collect psychiatric data and the annual data on menstrual cycle, biologic, symptom, functioning, psychosocial factors and serum hormones that the Core SWAN will no longer be collecting at the proposed 3 additional annual follow-ups. We will include 3 newly measured factors: specific genetic polymorphisms, family history of depression, and coping with the menopausal transition. Surprisingly little is known about depression during the menopausal transition and early postmenopause years when medical morbidity is increasing and about the effect of the transition on various patterns of depression. Continuing to follow this large, ethnically and socioeconomically diverse cohort will permit observation of the completed menopausal transition and the early postmenopause years in the entire aging cohort. The wealth of unique and valuable data on psychiatric, biologic, lifestyle, demographic, and psychosocial factors will advance our knowledge of the multiple determinants of depression and its course as women age. Increasing knowledge of the risks for depression in aging women and the factors that protect them from depression can identify targets for intervention at the prevention as well as the acute treatment level.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH059689-11
Application #
7793476
Study Section
Adult Psychopathology and Disorders of Aging Study Section (APDA)
Program Officer
Evans, Jovier D
Project Start
1999-08-15
Project End
2013-03-31
Budget Start
2010-04-01
Budget End
2013-03-31
Support Year
11
Fiscal Year
2010
Total Cost
$260,990
Indirect Cost
Name
University of Pittsburgh
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Colvin, Alicia; Richardson, Gale A; Cyranowski, Jill M et al. (2017) The role of family history of depression and the menopausal transition in the development of major depression in midlife women: Study of women's health across the nation mental health study (SWAN MHS). Depress Anxiety 34:826-835
Bromberger, Joyce T; Kravitz, Howard M; Youk, Ada et al. (2016) Patterns of depressive disorders across 13 years and their determinants among midlife women: SWAN mental health study. J Affect Disord 206:31-40
Bromberger, J T; Schott, L; Kravitz, H M et al. (2015) Risk factors for major depression during midlife among a community sample of women with and without prior major depression: are they the same or different? Psychol Med 45:1653-64
Matthews, Karen A; Chang, Yue-Fang; Thurston, Rebecca C et al. (2014) Child abuse is related to inflammation in mid-life women: role of obesity. Brain Behav Immun 36:29-34
Kravitz, H M; Schott, L L; Joffe, H et al. (2014) Do anxiety symptoms predict major depressive disorder in midlife women? The Study of Women's Health Across the Nation (SWAN) Mental Health Study (MHS). Psychol Med 44:2593-602
Colvin, Alicia; Richardson, Gale A; Cyranowski, Jill M et al. (2014) Does family history of depression predict major depression in midlife women? Study of Women's Health Across the Nation Mental Health Study (SWAN MHS). Arch Womens Ment Health 17:269-78
Midei, Aimee J; Matthews, Karen A; Chang, Yue-Fang et al. (2013) Childhood physical abuse is associated with incident metabolic syndrome in mid-life women. Health Psychol 32:121-7
Bromberger, Joyce T; Kravitz, Howard M; Chang, Yuefang et al. (2013) Does risk for anxiety increase during the menopausal transition? Study of women's health across the nation. Menopause 20:488-95
Bromberger, Joyce T; Schott, Laura L; Matthews, Karen A et al. (2012) Association of past and recent major depression and menstrual characteristics in midlife: Study of Women's Health Across the Nation. Menopause 19:959-66
Joffe, Hadine; Chang, Yuefang; Dhaliwal, Sammy et al. (2012) Lifetime history of depression and anxiety disorders as a predictor of quality of life in midlife women in the absence of current illness episodes. Arch Gen Psychiatry 69:484-92

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