Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH059842-02
Application #
6186768
Study Section
Special Emphasis Panel (ZRG1-MDCN-1 (01))
Project Start
1999-04-01
Project End
2004-03-31
Budget Start
2000-04-01
Budget End
2001-03-31
Support Year
2
Fiscal Year
2000
Total Cost
$225,814
Indirect Cost
Name
University of Washington
Department
Pharmacology
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Nowack, Amy; Malarkey, Erik B; Yao, Jia et al. (2011) Levetiracetam reverses synaptic deficits produced by overexpression of SV2A. PLoS One 6:e29560
Sgro, Allyson E; Nowak, Amy L; Austin, Naola S et al. (2011) A high-throughput method for generating uniform microislands for autaptic neuronal cultures. J Neurosci Methods 198:230-5
Nowack, Amy; Yao, Jia; Custer, Kenneth L et al. (2010) SV2 regulates neurotransmitter release via multiple mechanisms. Am J Physiol Cell Physiol 299:C960-7
Yao, Jia; Nowack, Amy; Kensel-Hammes, Patricia et al. (2010) Cotrafficking of SV2 and synaptotagmin at the synapse. J Neurosci 30:5569-78
Morgans, Catherine W; Kensel-Hammes, Patricia; Hurley, James B et al. (2009) Loss of the Synaptic Vesicle Protein SV2B results in reduced neurotransmission and altered synaptic vesicle protein expression in the retina. PLoS One 4:e5230
Yao, Jia; Bajjalieh, Sandra M (2009) SVOP is a nucleotide binding protein. PLoS One 4:e5315
Yao, Jia; Bajjalieh, Sandra M (2008) Synaptic vesicle protein 2 binds adenine nucleotides. J Biol Chem 283:20628-34
Custer, Kenneth L; Austin, Naola S; Sullivan, Jane M et al. (2006) Synaptic vesicle protein 2 enhances release probability at quiescent synapses. J Neurosci 26:1303-13
Schivell, Amanda E; Mochida, Sumiko; Kensel-Hammes, Patricia et al. (2005) SV2A and SV2C contain a unique synaptotagmin-binding site. Mol Cell Neurosci 29:56-64
Lynch, Berkley A; Lambeng, Nathalie; Nocka, Karl et al. (2004) The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. Proc Natl Acad Sci U S A 101:9861-6

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