Suicide attempts constitute a major risk factor for completed suicide. The current study aims to determine the efficacy and effectiveness of a short-tem cognitive therapy intervention for suicide attempters, implemented as soon as possible after a suicide attempt. The target group of suicide attempters, largely compromised of people from economically disadvantaged and minority groups, has a high rate of substance abuse. Our approach addresses the social as well as the psychological problems that contributes to suicide attempts in this disadvantaged group. The proposed intervention includes: (1) Cognitive and behavioral strategies that focus on the modifiable psychosocial risk factors including depression, hopelessness and suicide ideation, (2) problem-solving strategies, (3) utilization of social support, (4) addressing thoughts and beliefs that lead to substance abuse, and (5) increasing compliance with adjunctive medical, substance abuse, psychiatric and social interventions. In the research design, 120 patients evaluated at the emergency, medical, surgical, or psychiatric departments of a large urban hospital following a suicide attempt will be randomly assigned to cognitive therapy plus treatment-as-usual (CT+TAU) condition or to a treatment-as-usual condition. To test the generalizability of this intervention, all suicide attempters will be eligible for study participation. Patients in the CT+TAU condition will receive therapy immediately after the pre-treatment evaluation. The therapy will continue on a weekly basis post-hospitalization for ten sessions followed by booster sessions at the time of the post-treatment evaluations. All patients will receive in- hospital evaluations and then re-evaluations at 1, 3, 6, 12, 18 and 24 months after the suicide attempt. The primary outcome variable will be the incidence of subsequent suicide attempts. In addition, we will assess changes in hopelessness, depression, suicide ideation, appropriate health care utilization, cost-effectiveness and overall psychological and social adaptation. Analyses of repeated measures data will be performed for each measure to determine and characterize differences in the pattern of change over time between the two treatment conditions.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH060915-02
Application #
6330350
Study Section
Special Emphasis Panel (ZMH1-ITV-D (01))
Program Officer
Pearson, Jane L
Project Start
1999-12-15
Project End
2003-11-30
Budget Start
2001-12-01
Budget End
2002-11-30
Support Year
2
Fiscal Year
2002
Total Cost
$224,135
Indirect Cost
Name
University of Pennsylvania
Department
Psychiatry
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
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Gibbons, Carly J; Stirman, Shannon Wiltsey; Brown, Gregory K et al. (2010) Engagement and retention of suicide attempters in clinical research: challenges and solutions. Crisis 31:62-8
Spokas, Megan; Wenzel, Amy; Stirman, Shannon Wiltsey et al. (2009) Suicide risk factors and mediators between childhood sexual abuse and suicide ideation among male and female suicide attempters. J Trauma Stress 22:467-70
Have, Thomas R Ten; Joffe, Marshall M; Lynch, Kevin G et al. (2007) Causal mediation analyses with rank preserving models. Biometrics 63:926-34
Berk, Michele S; Jeglic, Elizabeth; Brown, Gregory K et al. (2007) Characteristics of recent suicide attempters with and without Borderline Personality Disorder. Arch Suicide Res 11:91-104
Henriques, Gregg; Wenzel, Amy; Brown, Gregory K et al. (2005) Suicide attempters' reaction to survival as a risk factor for eventual suicide. Am J Psychiatry 162:2180-2
Brown, Gregory K; Ten Have, Thomas; Henriques, Gregg R et al. (2005) Cognitive therapy for the prevention of suicide attempts: a randomized controlled trial. JAMA 294:563-70
Jeglic, Elizabeth L; Sharp, Ian R; Chapman, Jason E et al. (2005) History of family suicide behaviors and negative problem solving in multiple suicide attempters. Arch Suicide Res 9:135-46

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