The experiments proposed in this application will further understanding about why the experience of child abuse leads to a broad range of mental and physical health problems. Although millions of children experience various forms of child abuse each year in the United States, relatively little is understood about how this experience influences brain-behavioral development. The General Aim of this research is to examine how brain circuitry is shaped by environmental experience in ways that lead to childhood mental health problems. The research proposed in this application uses novel neuroscience-informed methods to measure the efficiency of emotional learning in 400 10-16 year old children, half of whom have been victims of child maltreatment.
The Specific Aims are to: (1) determine how children develop sensitivity to emotion-related contingencies in their environments, which is critical for understanding social behavior and related to problems such as anxiety and depression;(2) examine the efficiency with which children integrate and use emotional information using affective neuroscience markers of psychosocial stress as indicators of risk for mental illness;(3) test the extent to which the experience of early psychosocial stress undermines children's regulatory control of emotion processing, relevant to behaviors such as aggression and poor emotion regulation. In sum, this application proposes a continuing program of research that will examine altered emotional regulatory processes associated with child abuse. We will link these measures to mental health outcomes in early adolescents. This project has potential to synthesize key areas necessary to advance prevention and treatment of mental health problems in children and adults. Those include understanding (1) the neural circuitry and neurobiology of the brain's regulation of emotion, with an emphasis on understanding adaptations and squeal of chronic psychosocial stress exposure on affective neural circuits, (2) the development of these circuits, specifically the processes underlying periods of rapid neurobiological development in humans during which the brain may be particularly sensitive to contextual or environmental influences;and (3) defining and specifying ways in which the environment creates long-term effects on brain and behavior. Each of these foci holds tremendous promise for advancement of knowledge and application to improvement of public health.

Public Health Relevance

The research proposed in this application seeks to understand how the experience of child abuse exerts a lasting impact on children's brain development. Millions of children experience various forms of child abuse each year in the United States and it is known that these individuals are at heightened risk for a broad range of mental and physical health problems. But little is understood about how early experiences of psychosocial stress influence the neural systems that can lead to children's emotional and behavioral problems.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH061285-13
Application #
8695482
Study Section
Psychosocial Development, Risk and Prevention Study Section (PDRP)
Program Officer
Garvey, Marjorie A
Project Start
2000-04-01
Project End
2017-05-31
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
13
Fiscal Year
2014
Total Cost
$536,238
Indirect Cost
$174,565
Name
University of Wisconsin Madison
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Hanson, Jamie L; Nacewicz, Brendon M; Sutterer, Matthew J et al. (2015) Behavioral problems after early life stress: contributions of the hippocampus and amygdala. Biol Psychiatry 77:314-23
Leitzke, Brian T; Hilt, Lori M; Pollak, Seth D (2015) Maltreated youth display a blunted blood pressure response to an acute interpersonal stressor. J Clin Child Adolesc Psychol 44:305-13
Romens, Sarah E; McDonald, Jennifer; Svaren, John et al. (2015) Associations between early life stress and gene methylation in children. Child Dev 86:303-9
Shackman, Jessica E; Pollak, Seth D (2014) Impact of physical maltreatment on the regulation of negative affect and aggression. Dev Psychopathol 26:1021-33
Hilt, Lori M; Pollak, Seth D (2013) Characterizing the ruminative process in young adolescents. J Clin Child Adolesc Psychol 42:519-30
Hanson, Jamie L; Adluru, Nagesh; Chung, Moo K et al. (2013) Early neglect is associated with alterations in white matter integrity and cognitive functioning. Child Dev 84:1566-78
Romens, Sarah E; Pollak, Seth D (2012) Emotion regulation predicts attention bias in maltreated children at-risk for depression. J Child Psychol Psychiatry 53:120-7
Roeber, Barbara J; Tober, Christa L; Bolt, Daniel M et al. (2012) Gross motor development in children adopted from orphanage settings. Dev Med Child Neurol 54:527-31
Wiik, Kristen L; Loman, Michelle M; Van Ryzin, Mark J et al. (2011) Behavioral and emotional symptoms of post-institutionalized children in middle childhood. J Child Psychol Psychiatry 52:56-63
Strang, Nicole M; Pruessner, Jens; Pollak, Seth D (2011) Developmental changes in adolescentsýýý neural response to challenge. Dev Cogn Neurosci 1:560-9

Showing the most recent 10 out of 32 publications