Exposure to social stress has pervasive deleterious effects on health and is a primary risk factor for the development of depression and anxiety disorders. Despite the prevalence of these disorders, our current treatment strategies are woefully inadequate. One of the fundamental reasons that we have not developed better treatments is that these so-called pathological states likely stem from evolutionarily adaptive behavioral patterns that are adopted when individuals perceive social stress or defeat. This would help explain not only their prevalence but also their persistence. In many non-human species exposure to social stress also causes persistent physiological and behavioral responses that closely mimic the symptoms of depression and PTSD. What is desperately needed is an understanding of how social stress shifts behavior from one stable state to another. My lab has developed an ethologically relevant model in hamsters termed conditioned defeat (CD), wherein even a single exposure to social defeat stress causes a striking behavioral shift from social engagement and aggression to social avoidance and submission. The ultimate goal of our work is to delineate the neural mechanisms of such stress-induced shifts in behavioral state and to discover how these changes might be prevented or reversed. This project will test the overarching hypothesis that brain derived neurotrophic factor (BDNF) systems within specific regions of the CD neural circuit mediate, at least in part, behavioral changes observed following social defeat stress. We propose that BDNF can both promote and prevent these changes depending on the brain area involved (Aim 1) and that these actions are mediated by BDNF actions on tyrosine kinase B (TrkB) receptors (Aim 2). We also propose that chromatin remodeling of the BDNF gene and promoters is a molecular mechanism underlying the behavioral changes that define CD (Aim 3). In this project, we will not only delineate the site specific behavioral effects of, and defeat-induced epigenetic changes in, the BDNF-TrkB system in the neural circuit for CD, but we will also assess the translational potential of this informatin with systemic manipulations. Advancing our understanding of the mechanisms involved in shifts among stable behavioral states will dramatically advance our ability to treat intractable mood and anxiety disorders such as depression and PTSD.

Public Health Relevance

Exposure to social stress has pervasive deleterious effects on human health and is a major risk factor for the development of a variety of psychiatric disorders. Examination of ethologically relevant models of social stress in animals is critical for improving our understanding of how social stress produces these persistent deleterious effects, and advances in this area will result in improved strategies to treat and even prevent pathological responses to social stress in humans.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH062044-11
Application #
8666817
Study Section
Neurobiology of Motivated Behavior Study Section (NMB)
Program Officer
Simmons, Janine M
Project Start
2000-08-01
Project End
2018-03-31
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
11
Fiscal Year
2014
Total Cost
$370,000
Indirect Cost
$120,000
Name
Georgia State University
Department
Neurosciences
Type
Schools of Arts and Sciences
DUNS #
837322494
City
Atlanta
State
GA
Country
United States
Zip Code
30302
Song, Zhimin; McCann, Katharine E; McNeill 4th, John K et al. (2014) Oxytocin induces social communication by activating arginine-vasopressin V1a receptors and not oxytocin receptors. Psychoneuroendocrinology 50:14-9
McCann, Katharine E; Bicknese, Corinne N; Norvelle, Alisa et al. (2014) Effects of inescapable versus escapable social stress in Syrian hamsters: the importance of stressor duration versus escapability. Physiol Behav 129:25-9
Jeffress, Elizabeth C; Huhman, Kim L (2013) Copulatory and agonistic behavior in Syrian hamsters following social defeat. Aggress Behav 39:239-45
McDonald, Mark M; Markham, Chris M; Norvelle, Alisa et al. (2012) GABAA receptor activation in the lateral septum reduces the expression of conditioned defeat and increases aggression in Syrian hamsters. Brain Res 1439:27-33
Markham, Chris M; Luckett, Cloe A; Huhman, Kim L (2012) The medial prefrontal cortex is both necessary and sufficient for the acquisition of conditioned defeat. Neuropharmacology 62:933-9
Luckett, Cloe; Norvelle, Alisa; Huhman, Kim (2012) The role of the nucleus accumbens in the acquisition and expression of conditioned defeat. Behav Brain Res 227:208-14
McCann, Katharine E; Huhman, Kim L (2012) The effect of escapable versus inescapable social defeat on conditioned defeat and social recognition in Syrian hamsters. Physiol Behav 105:493-7
Day, Diane E; Cooper, Matthew A; Markham, Chris M et al. (2011) NR2B subunit of the NMDA receptor in the basolateral amygdala is necessary for the acquisition of conditioned defeat in Syrian hamsters. Behav Brain Res 217:55-9
Taylor, Stacie L; Stanek, Lisa M; Ressler, Kerry J et al. (2011) Differential brain-derived neurotrophic factor expression in limbic brain regions following social defeat or territorial aggression. Behav Neurosci 125:911-20
Cooper, Matthew A; Huhman, Kim L (2010) Blocking corticotropin-releasing factor-2 receptors, but not corticotropin-releasing factor-1 receptors or glucocorticoid feedback, disrupts the development of conditioned defeat. Physiol Behav 101:527-32

Showing the most recent 10 out of 30 publications