The aims of the proposed study are to reduce risk of HIV/STD transmission, reinfection and ARV drug resistance among culturally diverse HIV+/- women and their partners (HIV+ sero-concordant and sero- discordant couples) in the developed (Miami, Florida) and developing worlds (Lusaka, Zambia). The proposed study will compare the efficacy of gender-concordant Cognitive Behavioral Risk Reduction Group Counseling (Group Counseling) with traditional Safer Sex Couple Counseling (Couple Counseling) with the goals of 1) increasing partner participation in the use of barriers, 2) identifying interpersonal factors that influence sexual barrier acceptability, 3) developing and testing strategies to improve the acceptability and use of sexual barriers and 4) evaluating the impact of these strategies on long-term barrier maintenance. The current study, funded in 2000, has demonstrated this cognitive behavioral sexual risk reduction intervention to be effective with low SES minority women living with HIV in the US and Zambia. The intervention, tailored to these populations, focused on a) decreasing sexual risk behavior;b) increasing sexual barrier acceptability;and c) identifying factors that influence sexual barrier use. Preliminary data from our pilot work with male partners, however, has confirmed the need to expand our sexual behavior intervention to target both women and their male partners. Two hundred twenty HIV+ sero-concordant and sero-discordant couples at each site will be randomized to the two treatment conditions noted above and followed for one year. In addition to the primary aims related to barrier product acceptability, usage and maintenance, the role of sexual communication and negotiation will be considered as mediator/moderator variables of sexual risk behavior. Finally, intervention-related changes in ARV medication adherence will also be evaluated, as a means of preventing the transmission of drug-resistance strains of HIV among HIV+ and sero-discordant couples. Reducing HIV transmission and anti-retroviral drug resistance are principal goals of this proposed multisite study. A """"""""cognitive-behavioral"""""""" sexual risk reduction program promoting monogamy and use of sexual barrier methods (male and female condoms) will be compared to traditional HIV couples counseling for 440 HIV+ or serodiscordant couples in the developed world (Florida) and the developing world (Zambia) to improve primary and secondary prevention of HIV transmission among these vulnerable populations.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH063630-10
Application #
7738502
Study Section
Behavioral and Social Consequences of HIV/AIDS Study Section (BSCH)
Program Officer
Grossman, Cynthia I
Project Start
2000-09-30
Project End
2012-10-31
Budget Start
2009-11-20
Budget End
2012-10-31
Support Year
10
Fiscal Year
2010
Total Cost
$592,615
Indirect Cost
Name
University of Miami School of Medicine
Department
Psychiatry
Type
Schools of Medicine
DUNS #
052780918
City
Coral Gables
State
FL
Country
United States
Zip Code
33146
Jones, Deborah; Weiss, Stephen; Chitalu, Ndashi (2015) HIV Prevention in Resource Limited Settings: A Case Study of Challenges and Opportunities for Implementation. Int J Behav Med 22:384-92
Jones, Deborah; Kashy, Deborah; Chitalu, Ndashi et al. (2014) Risk reduction among HIV-seroconcordant and -discordant couples: the Zambia NOW2 intervention. AIDS Patient Care STDS 28:433-41
Jones, Deborah; Bagga, Rashmi; Nehra, Ritu et al. (2013) Reducing sexual risk behavior among high-risk couples in Northern India. Int J Behav Med 20:344-54
Jones, Deborah L; Kashy, Deborah; Villar-Loubet, Olga M et al. (2013) The impact of substance use, sexual trauma, and intimate partner violence on sexual risk intervention outcomes in couples: a randomized trial. Ann Behav Med 45:318-28
Jones, Deborah; Kashy, Deborah; Villar-Loubet, Olga et al. (2013) Enhancing acceptability and use of sexual barrier products among HIV concordant and discordant couples. AIDS Behav 17:2185-93
Villar-Loubet, Olga M; Vamos, Szonja; Jones, Deborah L et al. (2011) A Cultural Perspective on Sexual Health: HIV Positive and Negative Monolingual Hispanic Women in South Florida. Hisp Health Care Int 9:82-90
Weiss, Stephen M; Jones, Deborah L; Lopez, Maria et al. (2011) The many faces of translational research: a tale of two studies. Transl Behav Med 1:327-330
Villar-Loubet, Olga; Jones, Deborah; Waldrop-Valverde, Drenna et al. (2011) Sexual barrier acceptability among multiethnic HIV-positive and at-risk women. J Womens Health (Larchmt) 20:365-73
Lopez, Eliot J; Jones, Deborah L; Villar-Loubet, Olga M et al. (2010) Violence, coping, and consistent medication adherence in HIV-positive couples. AIDS Educ Prev 22:61-8
Jones, Deborah L; Weiss, Stephen M; Chitalu, Nadashi et al. (2008) Acceptability of microbicidal surrogates among Zambian women. Sex Transm Dis 35:147-53

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