The overall aim is to study the impact of a reduction of maternal depressive symptoms on children's psychiatric symptoms and social functioning, as an ancillary study to the multisite Sequenced Treatment Alternatives to Relieve Depression study (STAR D). Focusing on the common clinical question of what to do next when patients fail to respond to a standard trial of treatment, STAR D aims at defining which subsequent treatment strategies are acceptable and provide the best clinical results. This proposed ancillary study (STAR D-Child) takes advantage of a unique opportunity to follow a large culturally diverse sample of depressed mothers who will be treated, assessed and followed prospectively to determine the impact on their children. The proposed Child study is timed to coincide with the initiation of STAR D and has been approved by their ancillary studies committee. Previous studies have demonstrated that children of depressed mothers have over three-to five fivefold increased risk of serious and enduring problems. Little is known about the impact of remission of maternal depression on their offspring. The outcomes in the 8 to 16 year old children of mothers who experience a remission of their depression following exposure to a variety of treatments will be compared to children of mothers who remain depressed following exposure to treatment/s. Blind baseline and follow-up evaluations of children of mothers participating in the STAR D protocol and assessments of parenting and family functioning will be conducted in 327 mothers and 327 children in six sites. Assessments will be carried out a baseline and every three months. Children will be followed for 12 months after their mothers complete treatment. The main hypotheses are that children of treatment-responders will have fewer psychiatric symptoms and better social functioning than children of treatment-resistant mothers during the follow-up. Children of depressed mothers who spend a greater proportion of time during the follow-up interval in depression-remission will experience less symptoms and a higher level of functioning than children of mothers who remain depressed. Changes in parenting and family functioning will mediate the impact of maternal depression-remission; demographic, family composition, etc. will moderate the effect. If it is shown that successfully treating maternal depression is associated with diminished risk in offspring, the finding would have wide ranging public health implications.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
1R01MH063852-01
Application #
6364257
Study Section
Special Emphasis Panel (ZMH1-CRB-B (08))
Program Officer
Nottelmann, Editha
Project Start
2001-07-19
Project End
2006-06-30
Budget Start
2001-07-19
Budget End
2002-06-30
Support Year
1
Fiscal Year
2001
Total Cost
$1,200,901
Indirect Cost
Name
Columbia University (N.Y.)
Department
Psychiatry
Type
Schools of Medicine
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032
Cole, David A; Cho, Sun-Joo; Martin, Nina C et al. (2012) Are increased weight and appetite useful indicators of depression in children and adolescents? J Abnorm Psychol 121:838-51
Wickramaratne, Priya; Gameroff, Marc J; Pilowsky, Daniel J et al. (2011) Children of depressed mothers 1 year after remission of maternal depression: findings from the STAR*D-Child study. Am J Psychiatry 168:593-602
Cole, David A; Cai, Li; Martin, Nina C et al. (2011) Structure and measurement of depression in youths: applying item response theory to clinical data. Psychol Assess 23:819-33
Weissman, Myrna (2009) Depression. Ann Epidemiol 19:264-7
Weissman, Myrna M; Olfson, Mark (2009) Translating intergenerational research on depression into clinical practice. JAMA 302:2695-6
Weissman, Myrna M; Talati, Ardesheer (2009) Depression in at-risk adolescents and their parents. JAMA 302:1167; author reply 1167-8
Foster, Cynthia Ewell; Webster, Melissa C; Weissman, Myrna M et al. (2008) Remission of maternal depression: relations to family functioning and youth internalizing and externalizing symptoms. J Clin Child Adolesc Psychol 37:714-24
Gunlicks, Meredith L; Weissman, Myrna M (2008) Change in child psychopathology with improvement in parental depression: a systematic review. J Am Acad Child Adolesc Psychiatry 47:379-89
Pilowsky, Daniel J; Wickramaratne, Priya; Talati, Ardesheer et al. (2008) Children of depressed mothers 1 year after the initiation of maternal treatment: findings from the STAR*D-Child Study. Am J Psychiatry 165:1136-47
Talati, Ardesheer; Wickramaratne, Priya J; Pilowsky, Daniel J et al. (2007) Remission of maternal depression and child symptoms among single mothers: a STAR*D-Child report. Soc Psychiatry Psychiatr Epidemiol 42:962-71

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