The broad objective of the research proposed in this competing continuation application is to identify predictors of risky and safer sexual behavior and sexually transmitted disease (STD) among South African adolescents. This is a collaborative effort by a multidisciplinary team of researchers from the United States and the Republic of South Africa to conduct a long-term follow-up of an ongoing clustered randomized controlled trial of an HIV/STD risk-reduction behavioral intervention.
The Specific Aims are to (1) determine whether the effects of the HIV/STD risk-reduction intervention on self-reported sexual behavior are evident at 36-month and 48-month follow-up; (2) determine whether the intervention reduced the rate of clinically documented STDs; (3) identify participants' characteristics and theoretical mediator variables assessed at baseline that predict sexual-risk behavior at long-term follow-up; and (4) identify participants' characteristics and theoretical mediator variables assessed at baseline that predict STD incidence. The participants will be the 1,057 Xhosa-speaking grade 6 learners from the 18 schools in Mdantsane and Berlin in the Eastern Cape Province, South Africa who were randomized to Let Us Protect Our Future a 12-hour HIV/STD Risk- Reduction Intervention or a 12-hour health-promotion control intervention on health issues unrelated to sexual behavior. Male and female Xhosa-speaking co-facilitators from the community led both interventions. The theoretical basis of the interventions was social cognitive theory and the theory of planned behavior. Extensive formative research, pilot studies, and input from a Community Advisory Board were employed to ensure the contextual appropriateness of the interventions and other protocols. The participants will be about 16 years of age at the time of the proposed 48-month follow-up, an age at which many South African adolescents have their sexual debut. The proposed research, then, provides a unique opportunity to examine predictors of sexual risk behavior at a critical period in the development of South African adolescents. Confidential self-report questionnaires will be employed to assess sexual risk behaviors and theoretical variables hypothesized to mediate the intervention's effect on such behavior 36 months and 48 months postintervention. Urine specimens will be collected and tested for Chlamydia trachomatis, Neisseria gonorrhea, and Trichomonas vaginalis using DNA-amplification technology. To address the Specific Aims, we will analyze the data with generalized estimating equations (GEE) and random effects models. The results of this study will contribute to scientific knowledge regarding the long-term effects of HIV/STD risk- reduction interventions for South African adolescents and the predictors of sexual risk behavior and STD rates as the participants approach middle adolescence. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
2R01MH065867-06A1
Application #
7422216
Study Section
Behavioral and Social Science Approaches to Preventing HIV/AIDS Study Section (BSPH)
Program Officer
Brouwers, Pim
Project Start
2002-09-20
Project End
2010-08-31
Budget Start
2007-09-28
Budget End
2008-08-31
Support Year
6
Fiscal Year
2007
Total Cost
$690,256
Indirect Cost
Name
University of Pennsylvania
Department
Type
Other Domestic Higher Education
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Icard, Larry D; Jemmott, John B; Carty, Craig et al. (2017) Retention of South African Adolescents in a 54-Month Longitudinal HIV Risk Reduction Trial. Prev Sci 18:534-540
Teitelman, Anne M; Jemmott, John B; Bellamy, Scarlett L et al. (2016) Partner violence, power, and gender differences in South African adolescents' HIV/sexually transmitted infections risk behaviors. Health Psychol 35:751-760
Jemmott 3rd, John B; Jemmott, Loretta S; O'Leary, Ann et al. (2015) HIV/STI risk-reduction intervention efficacy with South African adolescents over 54 months. Health Psychol 34:610-21
O'Leary, Ann; Jemmott 3rd, John B; Jemmott, Loretta S et al. (2015) Associations between psychosocial factors and incidence of sexually transmitted disease among South African adolescents. Sex Transm Dis 42:135-9
O'Leary, Ann; Jemmott 3rd, John B; Stevens, Robin et al. (2014) Optimism and education buffer the effects of syndemic conditions on HIV status among African American men who have sex with men. AIDS Behav 18:2080-8
Heeren, G Anita; Icard, Larry D; O'Leary, Ann et al. (2014) Protective factors and HIV risk behavior among South African men. AIDS Behav 18:1991-7
Jemmott, L S; Jemmott 3rd, J B; Ngwane, Z et al. (2014) 'Let Us Protect Our Future' a culturally congruent evidenced-based HIV/STD risk-reduction intervention for young South African adolescents. Health Educ Res 29:166-81
O'Leary, Ann; Jemmott 3rd, John B; Jemmott, Loretta Sweet et al. (2012) Moderation and mediation of an effective HIV risk-reduction intervention for South African adolescents. Ann Behav Med 44:181-91
Heeren, G Anita; Jemmott 3rd, John B; Sidloyi, Lulama et al. (2012) Disclosure of HIV Diagnosis to HIV-Infected Children in South Africa: Focus Groups for Intervention Development. Vulnerable Child Youth Stud 7:47-54
Jemmott 3rd, John B; Jemmott, Loretta S; O'Leary, Ann et al. (2011) Cognitive-behavioural health-promotion intervention increases fruit and vegetable consumption and physical activity among South African adolescents: a cluster-randomised controlled trial. Psychol Health 26:167-85

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