The ability to learn and remember is a critical survival skill whether you are a human or a fly. This proposal will exploit the behavioral and genetic richness of Drosophila to define and understand neuronal circuits that link sleep and memory. Humans spend roughly one third of their lives asleep. Amazingly, there is no consensus on why we and other animals sleep, only agreement that without sleep our brains do not function optimally. One recurring finding, with convincing data from humans, mammalian model systems, and Drosophila is that sleep is required for effective memory formation. We will investigate the role of the circadian clock in both sleep (Specific Aim #1) and memory formation (Specific Aim #2) using cell specific manipulations that alter neuronal excitability. We will identify and characterize the activity of cells that are downstream of the clock that generate sleep (Specific Aim #3).

Public Health Relevance

Lack of sleep is an increasingly serious human health problem in western society. Studies of the the linkage between sleep and memory in Drosophila will provide insight into how sleep affects learning in humans.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH067284-09
Application #
8196942
Study Section
Neurobiology of Learning and Memory Study Section (LAM)
Program Officer
Asanuma, Chiiko
Project Start
2002-10-01
Project End
2013-11-30
Budget Start
2011-12-01
Budget End
2012-11-30
Support Year
9
Fiscal Year
2012
Total Cost
$391,050
Indirect Cost
$143,550
Name
Brandeis University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
616845814
City
Waltham
State
MA
Country
United States
Zip Code
02454
Parisky, Katherine M; Agosto Rivera, José L; Donelson, Nathan C et al. (2016) Reorganization of Sleep by Temperature in Drosophila Requires Light, the Homeostat, and the Circadian Clock. Curr Biol 26:882-92
Guo, Fang; Yu, Junwei; Jung, Hyung Jae et al. (2016) Circadian neuron feedback controls the Drosophila sleep--activity profile. Nature 536:292-7
Haynes, Paula R; Christmann, Bethany L; Griffith, Leslie C (2015) A single pair of neurons links sleep to memory consolidation in Drosophila melanogaster. Elife 4:
Langenhan, Tobias; Barr, Maureen M; Bruchas, Michael R et al. (2015) Model Organisms in G Protein-Coupled Receptor Research. Mol Pharmacol 88:596-603
Liu, Chang; Haynes, Paula R; Donelson, Nathan C et al. (2015) Sleep in Populations of Drosophila Melanogaster (1,2,3). eNeuro 2:
Griffith, Leslie C (2014) Up all night on a redeye flight. Elife 3:e02087
Griffith, Leslie C (2014) A big picture of a small brain. Elife 3:e05580
Vecsey, Christopher G; Pirez, Nicolas; Griffith, Leslie C (2014) The Drosophila neuropeptides PDF and sNPF have opposing electrophysiological and molecular effects on central neurons. J Neurophysiol 111:1033-45
Chi, Michael W; Griffith, Leslie C; Vecsey, Christopher G (2014) Larval Population Density Alters Adult Sleep in Wild-Type Drosophila melanogaster but Not in Amnesiac Mutant Flies. Brain Sci 4:453-70
Ni, Lina; Bronk, Peter; Chang, Elaine C et al. (2013) A gustatory receptor paralogue controls rapid warmth avoidance in Drosophila. Nature 500:580-4

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