The ability to time underlies adaptive behavior. Skilled motor sequences are carefully timed. Decisions about whether or not to take an action depend on knowledge of when they are appropriate. Memories for how long actions usually take underlies most ordinary activity such as planning a day or knowing how long it takes to cross a street. This learning of time is largely automatic is a foundation of behavioral organization. Disordered timing and distorted anticipation are associated with a number of psychiatric disorders including attention deficit hyperactivity disorder, schizophrenia and depression. The purpose of this grant is to understand how times are learned, remembered and used to guide behavior.
There are deficits in timing and anticipation in many behavior disorders. Depression, schizophrenia and attention-deficit-hyperactivity disorder are all associated with distortions in time perception and changes in the capacity to anticipate predictable events. Drug-taking and other habitual high-risk behaviors are associated with diminished capacity to anticipate long-term consequences. An understanding of the mechanisms of anticipatory learning will lead to more widespread and effective behavioral and biological treatments.
|Parnaudeau, Sébastien; Taylor, Kathleen; Bolkan, Scott S et al. (2015) Mediodorsal thalamus hypofunction impairs flexible goal-directed behavior. Biol Psychiatry 77:445-53|
|Taylor, Kathleen M; Joseph, Victory; Zhao, Alice S et al. (2014) Temporal maps in appetitive Pavlovian conditioning. Behav Processes 101:15-22|
|Gallistel, Charles R; Balsam, Peter D (2014) Time to rethink the neural mechanisms of learning and memory. Neurobiol Learn Mem 108:136-44|
|Jensen, Greg; Stokes, Patricia D; Paterniti, Anthea et al. (2014) Unexpected downshifts in reward magnitude induce variation in human behavior. Psychon Bull Rev 21:436-44|
|Markou, Athina; Salamone, John D; Bussey, Timothy J et al. (2013) Measuring reinforcement learning and motivation constructs in experimental animals: relevance to the negative symptoms of schizophrenia. Neurosci Biobehav Rev 37:2149-65|
|Trifilieff, P; Feng, B; Urizar, E et al. (2013) Increasing dopamine D2 receptor expression in the adult nucleus accumbens enhances motivation. Mol Psychiatry 18:1025-33|
|Ward, Ryan D; Simpson, Eleanor H; Richards, Vanessa L et al. (2012) Dissociation of hedonic reaction to reward and incentive motivation in an animal model of the negative symptoms of schizophrenia. Neuropsychopharmacology 37:1699-707|
|Choi, Won Yung; Campbell, Cecile Morvan; Balsam, Peter D et al. (2011) Effects of cortical and striatal dopamine D1 receptor blockade on cued versus noncued behavioral responses. Behav Neurosci 125:705-13|
|Silver, Rae; Balsam, Peter D; Butler, Matthew P et al. (2011) Food anticipation depends on oscillators and memories in both body and brain. Physiol Behav 104:562-71|
|Simpson, Eleanor H; Kellendonk, Christoph; Ward, Ryan D et al. (2011) Pharmacologic rescue of motivational deficit in an animal model of the negative symptoms of schizophrenia. Biol Psychiatry 69:928-35|
Showing the most recent 10 out of 27 publications