Major Depressive Disorder (MDD) is one of the most prevalent mental disorders, and is associated with significant mortality, morbidity, and economic costs. The Stony Brook Temperament Study is an ongoing longitudinal study that seeks to identify early behavioral precursors/risk factors for depression and understand the neurobiological and psychosocial processes through which these early manifestations develop into MDD. This information about risk pathways and processes should contribute to understanding when and how to intervene in order to prevent the disorder and limit its progression. The study initially assessed a large community sample of 3-year old children, followed them up at age 6, and is currently evaluating them in middle childhood (age 9). This competing renewal application seeks to extend the study into adolescence, the beginning of the peak risk period for onset of MDD. Specifically, the application proposes to map pathways from laboratory observations of low positive emotionality and high negative emotionality at age 3 to neural indices of emotional and social information processing, hypothalamic-pituitary-adrenal axis dysregulation, and emerging depressive and anxiety symptoms in early- (age 12) and mid- (age 15) adolescence. In addition, it seeks to understand the role of pubertal development and life stress in influencing these trajectories, and to capture the early portion of the expected sure in first-onset MDD that begins at puberty and continues through early adulthood.

Public Health Relevance

The depressive disorders are highly prevalent and associated with significant mortality, morbidity, and economic costs. This project seeks to identify early behavioral precursors/risk factors for major depressive disorder and understand the neurobiological and psychosocial processes through which these early manifestations develop into clinically significant psychopathology. This will contribute to understanding when and how to intervene in order to prevent the disorder and/or its progression.

Agency
National Institute of Health (NIH)
Type
Research Project (R01)
Project #
2R01MH069942-10
Application #
8574224
Study Section
Child Psychopathology and Developmental Disabilities Study Section (CPDD)
Program Officer
Garriock, Holly A
Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
2014
Total Cost
Indirect Cost
Name
State University New York Stony Brook
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
City
Stony Brook
State
NY
Country
United States
Zip Code
11794
Kopala-Sibley, D C; Kotov, R; Bromet, E J et al. (2016) Personality diatheses and Hurricane Sandy: effects on post-disaster depression. Psychol Med 46:865-75
Kujawa, Autumn; Hajcak, Greg; Danzig, Allison P et al. (2016) Neural Reactivity to Emotional Stimuli Prospectively Predicts the Impact of a Natural Disaster on Psychiatric Symptoms in Children. Biol Psychiatry 80:381-9
Dougherty, L R; Smith, V C; Bufferd, S J et al. (2016) Disruptive mood dysregulation disorder at the age of 6 years and clinical and functional outcomes 3 years later. Psychol Med 46:1103-14
Allmann, Anna E S; Kopala-Sibley, Daniel C; Klein, Daniel N (2016) Preschoolers' Psychopathology and Temperament Predict Mothers' Later Mood Disorders. J Abnorm Child Psychol 44:421-32
Huang, Anna S; Klein, Daniel N; Leung, Hoi-Chung (2016) Load-related brain activation predicts spatial working memory performance in youth aged 9-12 and is associated with executive function at earlier ages. Dev Cogn Neurosci 17:1-9
Johnson, Victoria C; Olino, Thomas M; Klein, Daniel N et al. (2016) A Longitudinal Investigation of Predictors of the Association Between Age 3 and Age 6 Behavioural Inhibition. J Res Pers 63:51-61
Carlson, Gabrielle A; Danzig, Allison P; Dougherty, Lea R et al. (2016) Loss of Temper and Irritability: The Relationship to Tantrums in a Community and Clinical Sample. J Child Adolesc Psychopharmacol 26:114-22
Kessel, Ellen M; Dougherty, Lea R; Kujawa, Autumn et al. (2016) Longitudinal Associations Between Preschool Disruptive Mood Dysregulation Disorder Symptoms and Neural Reactivity to Monetary Reward During Preadolescence. J Child Adolesc Psychopharmacol 26:131-7
Kotelnikova, Yuliya; Olino, Thomas M; Klein, Daniel N et al. (2016) Higher- and lower-order factor analyses of the Children's Behavior Questionnaire in early and middle childhood. Psychol Assess 28:92-108
Kessel, Ellen M; Nelson, Brady D; Kujawa, Autumn et al. (2016) Hurricane Sandy Exposure Alters the Development of Neural Reactivity to Negative Stimuli in Children. Child Dev :

Showing the most recent 10 out of 77 publications