The overarching goal of the proposed research is to understand, from a cognitive neuroscience perspective, how information about an event is successfully retrieved from episodic memory. Functional magnetic resonance imaging (fMRI) and event-related potentials (ERPs) will be employed to identify neural activity elicited during the retrieval of experimental items such as words and pictures. One line of experiments will investigate the extent to which retrieval-related activity in the hippocampus selectively supports the recovery of qualitative information about the past. Other experiments will investigate the degree to which retrieval-related activity in different parts of the medial temporal lobe dissociates according to whether associations between items, or items and their contexts, are recollected. A third set of experiments will investigate the generality and functional significance of content-selective, retrieval-related cortical reinstatement effects. A final set of experiments will focus of the functional significance of retrieval-related activity in inferior posterior parietal cortex. These last experiments will take as their starting point the hypothesis that this region supports an 'episodic buffer'that serves as an interface between episodic and working memory, and facilitates conscious access to recollected information. Disabling impairments of episodic memory are prominent in several common neurological conditions, notably Alzheimer's disease and traumatic brain injury. Episodic memory dysfunction is also a significant component of several common psychiatric disorders, including schizophrenia, depression and post-traumatic stress disorder. In addition, episodic memory declines substantially and, relative to other kinds of memory, disproportionately, with increasing age. The proposed research will facilitate the detailed understanding of the neurocognitive processes that support normally-functioning episodic memory, an understanding that is necessary for the elucidation of different kinds of episodic memory disorders and the development of effective therapeutic interventions.

Public Health Relevance

Disabling impairments of episodic memory - memory for unique events - are found in numerous neurological and psychiatric conditions. The proposed research will contribute to the detailed understanding of normally-functioning episodic memory that is necessary if different kinds of episodic memory disorders are to be fully understood and effectively treated.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Research Project (R01)
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Special Emphasis Panel (ZRG1-BBBP-D (06))
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Osborn, Bettina D
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University of Texas-Dallas
Other Domestic Higher Education
United States
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Elward, Rachael L; Vilberg, Kaia L; Rugg, Michael D (2015) Motivated Memories: Effects of Reward and Recollection in the Core Recollection Network and Beyond. Cereb Cortex 25:3159-66
Vilberg, Kaia L; Rugg, Michael D (2014) Temporal dissociations within the core recollection network. Cogn Neurosci 5:77-84
Rugg, Michael D; Vilberg, Kaia L (2013) Brain networks underlying episodic memory retrieval. Curr Opin Neurobiol 23:255-60
Okada, Kayoko; Vilberg, Kaia L; Rugg, Michael D (2012) Comparison of the neural correlates of retrieval success in tests of cued recall and recognition memory. Hum Brain Mapp 33:523-33
Hayama, Hiroki R; Vilberg, Kaia L; Rugg, Michael D (2012) Overlap between the neural correlates of cued recall and source memory: evidence for a generic recollection network? J Cogn Neurosci 24:1127-37
Suzuki, Maki; Johnson, Jeffrey D; Rugg, Michael D (2011) Decrements in hippocampal activity with item repetition during continuous recognition: an fMRI study. J Cogn Neurosci 23:1522-32
Suzuki, Maki; Johnson, Jeffrey D; Rugg, Michael D (2011) Recollection-related hippocampal activity during continuous recognition: a high-resolution fMRI study. Hippocampus 21:575-83
Yu, Sarah S; Rugg, Michael D (2010) Dissociation of the electrophysiological correlates of familiarity strength and item repetition. Brain Res 1320:74-84
Hayama, Hiroki R; Rugg, Michael D (2009) Right dorsolateral prefrontal cortex is engaged during post-retrieval processing of both episodic and semantic information. Neuropsychologia 47:2409-16
Jaeger, Antonio; Johnson, Jeffrey D; Corona, Maria et al. (2009) ERP correlates of the incidental retrieval of emotional information: effects of study-test delay. Brain Res 1269:105-13

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