Despite considerable scientific progress over the past 15 years, notable limitations persist in the theoretical and clinical significance of memory assessment in persons with HIV-1 infection. The overarching aim of this revised multidisciplinary project is to provide a conceptually-driven approach to delineating the impact of HIV-1 infection on prospective memory (ProM). ProM is a unique aspect of episodic memory sensitive to fronto-striatal damage that encompasses the complex processes of forming, monitoring, and executing future intentions vis-a-vis ongoing distractions. Consideration of ProM can enhance prediction of- and interventions related to - instrumental activities of daily living (lADLs). It is therefore surprising that ProM has not been evaluated in HIV-1, especially given the fronto-striatal neuropathogenesis of HIV-1-associated memory deficits and their impact on lADLs. Accordingly, this revised research application is guided by the following specific aims: 1) to clarify the nature, extent, and disease correlates of ProM impairment in HIV-1 infection; 2) to delineate the cognitive mechanisms of ProM impairment in HIV-1 using both clinical and experimental measures; and 3) to assess the efficacy of ProM in predicting lADLs (e.g., medication adherence) in HIV-1. We will recruit 200 HIV+ participants and 50 demographically comparable controls to evaluate the following primary hypotheses: 1) HIV-1 infection is associated with deficient executive control of encoding and retrieval within ProM; 2) ProM impairment is associated with advanced HIV-1 disease (e.g., viral load); and 3) ProM provides incremental validity relative to traditional cognitive tests in predicting lADLs, including medication adherence. This study promises to produce important conceptual and practical innovations regarding the nature and clinical assessment of HIV-associated cognitive disorders, and may ultimately facilitate the development of ProM-based interventions to minimize the impact of cognitive disorders on persons with HIV-1 infection, caregivers, and the health care system.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH073419-02
Application #
7026523
Study Section
Special Emphasis Panel (ZRG1-AARR-G (02))
Program Officer
Stoff, David M
Project Start
2005-03-04
Project End
2008-02-29
Budget Start
2006-03-01
Budget End
2007-02-28
Support Year
2
Fiscal Year
2006
Total Cost
$309,316
Indirect Cost
Name
University of California San Diego
Department
Psychiatry
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Anderson, Albert M; Croteau, David; Ellis, Ronald J et al. (2018) HIV, prospective memory, and cerebrospinal fluid concentrations of quinolinic acid and phosphorylated Tau. J Neuroimmunol 319:13-18
Sheppard, David P; Woods, Steven Paul; Verduzco, Marizela et al. (2018) Construct validity of the UCSD performance-based skills assessment-brief version (UPSA-B) in HIV disease. Appl Neuropsychol Adult 25:543-554
Morgan, Erin E; Woods, Steven Paul; Iudicello, Jennifer E et al. (2018) Poor Self-efficacy for Healthcare Provider Interactions Among Individuals with HIV-Associated Neurocognitive Disorders. J Clin Psychol Med Settings :
Harris, Lynnette L; Chernoff, Miriam C; Nichols, Sharon L et al. (2018) Prospective memory in youth with perinatally-acquired HIV infection. Child Neuropsychol 24:938-958
Garvie, Patricia A; Nichols, Sharon L; Williams, Paige L et al. (2018) Development and reliability of the Prospective Memory Assessment for Children & Youth (PROMACY): A preliminary study in a nonclinical sample. Appl Neuropsychol Child :1-14
Faytell, Marika Pers; Doyle, Katie; Naar-King, Sylvie et al. (2018) Calendaring and alarms can improve naturalistic time-based prospective memory for youth infected with HIV. Neuropsychol Rehabil 28:1038-1051
Sullivan, Kelli L; Woods, Steven Paul; Bucks, Romola S et al. (2018) Intraindividual variability in neurocognitive performance is associated with time-based prospective memory in older adults. J Clin Exp Neuropsychol 40:733-743
Avci, Gunes; Sheppard, David P; Tierney, Savanna M et al. (2018) A systematic review of prospective memory in HIV disease: from the laboratory to daily life. Clin Neuropsychol 32:858-890
Kordovski, Victoria M; Woods, Steven Paul; Verduzco, Marizela et al. (2017) The effects of aging and HIV disease on employment status and functioning. Rehabil Psychol 62:591-599
Oliveira, Michelli F; Chaillon, Antoine; Nakazawa, Masato et al. (2017) Early Antiretroviral Therapy Is Associated with Lower HIV DNA Molecular Diversity and Lower Inflammation in Cerebrospinal Fluid but Does Not Prevent the Establishment of Compartmentalized HIV DNA Populations. PLoS Pathog 13:e1006112

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