The medial temporal lobes (MTL) are the critical substrate for episodic memory. It is undisputed that a division of labor exists within the MTL. However, there is very little consensus as to how to best characterize these distinctions. Although some convergent evidence exists for a division of labor, particularly concerning the distinction between perirhinal and hippocampal encoding processes, the nature of the distinction between perirhinal and parahippocampal cortex has been underspecified. Although there is strong convergence in the literature supporting a role for the hippocampus in relational processing, the role of the MTL cortex in item processing/familiarity is less well defined, and only partially supported by the literature. Importantly, investigation into the extent and form of domain specificity within MTL cortex will contribute substantially to our understanding of episodic memory function. A fundamental hallmark of normal and abnormal aging, as well as some psychopathologies, is the alteration in episodic memory. Through an understanding of the functional architecture of the episodic memory system, great insight can be gleaned into these memory related deficits that, for example, occur during disease progression as a consequence of Alzheimer's disease or have been seen in the pathophysiology of neuropsychiatric disorders such as depression and schizophrenia. Understanding the neural mechanisms underlying the formation of human memory is an important step in efforts to describe and treat conditions that impact memory and will, thus, have a great impact on public health issues regarding treatment of such conditions. The research proposed will use functional magnetic resonance imaging to elucidate the functions of the MTL considering informational domain as being critical to a complete model of MTL organization (Aims 1 and 2). In addition, whether relational encoding and retrieval, thought to be a hallmark of hippocampal function, extends to the binding of episodic events in time will be explored (AIM 3)

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH074692-05
Application #
8013042
Study Section
Neurobiology of Learning and Memory Study Section (LAM)
Program Officer
Osborn, Bettina D
Project Start
2007-01-01
Project End
2012-02-23
Budget Start
2011-01-01
Budget End
2012-02-23
Support Year
5
Fiscal Year
2011
Total Cost
$299,144
Indirect Cost
Name
New York University
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
041968306
City
New York
State
NY
Country
United States
Zip Code
10012
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DuBrow, Sarah; Davachi, Lila (2016) Temporal binding within and across events. Neurobiol Learn Mem 134 Pt A:107-14
Heusser, Andrew C; Poeppel, David; Ezzyat, Youssef et al. (2016) Episodic sequence memory is supported by a theta-gamma phase code. Nat Neurosci 19:1374-80
Tompary, Alexa; Duncan, Katherine; Davachi, Lila (2016) High-resolution investigation of memory-specific reinstatement in the hippocampus and perirhinal cortex. Hippocampus 26:995-1007
Danker, Jared F; Tompary, Alexa; Davachi, Lila (2016) Trial-by-Trial Hippocampal Encoding Activation Predicts the Fidelity of Cortical Reinstatement During Subsequent Retrieval. Cereb Cortex :
Davachi, Lila; DuBrow, Sarah (2015) How the hippocampus preserves order: the role of prediction and context. Trends Cogn Sci 19:92-9
Yushkevich, Paul A; Amaral, Robert S C; Augustinack, Jean C et al. (2015) Quantitative comparison of 21 protocols for labeling hippocampal subfields and parahippocampal subregions in in vivo MRI: towards a harmonized segmentation protocol. Neuroimage 111:526-41
Murty, Vishnu P; DuBrow, Sarah; Davachi, Lila (2015) The simple act of choosing influences declarative memory. J Neurosci 35:6255-64
Schiller, Daniela; Eichenbaum, Howard; Buffalo, Elizabeth A et al. (2015) Memory and Space: Towards an Understanding of the Cognitive Map. J Neurosci 35:13904-11
Tompary, Alexa; Duncan, Katherine; Davachi, Lila (2015) Consolidation of Associative and Item Memory Is Related to Post-Encoding Functional Connectivity between the Ventral Tegmental Area and Different Medial Temporal Lobe Subregions during an Unrelated Task. J Neurosci 35:7326-31

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