Maintaining healthy cognitive functions, of which memory is a most important one, is one of the major goals of mental health research. Aging, diseases, stress and injury can lead to cognitive and memory impairments. It is estimated that up to one third of adults will experience a gradual decline in cognitive function known as mild cognitive impairment as they age. Furthermore, risk for Alzheimer

Public Health Relevance

Capitalizing on recent findings from our ongoing project using the rat as an animal model, this project continuation aims at identifying the mechanisms and circuitry of memory enhancement in adult animals and in preventing or rescuing memory decay. The results of these studies may lead to the identification of new therapies that prevent or reverse memory impairments. Preventing or rescuing cognitive and memory loss is a most important goal in mental health research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
2R01MH074736-06
Application #
8204300
Study Section
Special Emphasis Panel (ZRG1-IFCN-C (04))
Program Officer
Osborn, Bettina D
Project Start
2005-07-01
Project End
2016-11-30
Budget Start
2012-02-06
Budget End
2012-11-30
Support Year
6
Fiscal Year
2012
Total Cost
$643,292
Indirect Cost
$219,352
Name
New York University
Department
Neurology
Type
Schools of Arts and Sciences
DUNS #
041968306
City
New York
State
NY
Country
United States
Zip Code
10012
Travaglia, Alessio; Bisaz, Reto; Cruz, Emmanuel et al. (2016) Developmental changes in plasticity, synaptic, glia and connectivity protein levels in rat dorsal hippocampus. Neurobiol Learn Mem 135:125-138
Travaglia, Alessio; Bisaz, Reto; Sweet, Eric S et al. (2016) Infantile amnesia reflects a developmental critical period for hippocampal learning. Nat Neurosci 19:1225-33
Steinmetz, Adam B; Johnson, Sarah A; Iannitelli, Dylan E et al. (2016) Insulin-like growth factor 2 rescues aging-related memory loss in rats. Neurobiol Aging 44:9-21
Finsterwald, Charles; Steinmetz, Adam B; Travaglia, Alessio et al. (2015) From Memory Impairment to Posttraumatic Stress Disorder-Like Phenotypes: The Critical Role of an Unpredictable Second Traumatic Experience. J Neurosci 35:15903-15
Finsterwald, Charles; Alberini, Cristina M (2014) Stress and glucocorticoid receptor-dependent mechanisms in long-term memory: from adaptive responses to psychopathologies. Neurobiol Learn Mem 112:17-29
Bisaz, Reto; Travaglia, Alessio; Alberini, Cristina M (2014) The neurobiological bases of memory formation: from physiological conditions to psychopathology. Psychopathology 47:347-56
Stern, Sarah A; Kohtz, Amy S; Pollonini, Gabriella et al. (2014) Enhancement of memories by systemic administration of insulin-like growth factor II. Neuropsychopharmacology 39:2179-90
Stern, Sarah A; Alberini, Cristina M (2013) Mechanisms of memory enhancement. Wiley Interdiscip Rev Syst Biol Med 5:37-53
Arguello, Amy A; Ye, Xiaojing; Bozdagi, Ozlem et al. (2013) CCAAT enhancer binding protein δ plays an essential role in memory consolidation and reconsolidation. J Neurosci 33:3646-58
Alberini, Cristina M; Chen, Dillon Y (2012) Memory enhancement: consolidation, reconsolidation and insulin-like growth factor 2. Trends Neurosci 35:274-83

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