Maintaining healthy cognitive functions, of which memory is a most important one, is one of the major goals of mental health research. Aging, diseases, stress and injury can lead to cognitive and memory impairments. It is estimated that up to one third of adults will experience a gradual decline in cognitive function known as mild cognitive impairment as they age. Furthermore, risk for Alzheimer

Public Health Relevance

Capitalizing on recent findings from our ongoing project using the rat as an animal model, this project continuation aims at identifying the mechanisms and circuitry of memory enhancement in adult animals and in preventing or rescuing memory decay. The results of these studies may lead to the identification of new therapies that prevent or reverse memory impairments. Preventing or rescuing cognitive and memory loss is a most important goal in mental health research.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Research Project (R01)
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Study Section
Special Emphasis Panel (ZRG1-IFCN-C (04))
Program Officer
Osborn, Bettina D
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New York University
Schools of Arts and Sciences
New York
United States
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Travaglia, Alessio; Bisaz, Reto; Cruz, Emmanuel et al. (2016) Developmental changes in plasticity, synaptic, glia and connectivity protein levels in rat dorsal hippocampus. Neurobiol Learn Mem 135:125-138
Travaglia, Alessio; Bisaz, Reto; Sweet, Eric S et al. (2016) Infantile amnesia reflects a developmental critical period for hippocampal learning. Nat Neurosci 19:1225-33
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Stern, Sarah A; Kohtz, Amy S; Pollonini, Gabriella et al. (2014) Enhancement of memories by systemic administration of insulin-like growth factor II. Neuropsychopharmacology 39:2179-90
Stern, Sarah A; Alberini, Cristina M (2013) Mechanisms of memory enhancement. Wiley Interdiscip Rev Syst Biol Med 5:37-53
Arguello, Amy A; Ye, Xiaojing; Bozdagi, Ozlem et al. (2013) CCAAT enhancer binding protein δ plays an essential role in memory consolidation and reconsolidation. J Neurosci 33:3646-58
Alberini, Cristina M; Chen, Dillon Y (2012) Memory enhancement: consolidation, reconsolidation and insulin-like growth factor 2. Trends Neurosci 35:274-83

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